Table 1.

Baseline biochemistry according to MTHFR C677T genotype

VariableMTHFR C677T genotype
CCCTTTAll
Plasma 5MeTHF (nmol/L)N727716165
Mean39.8643.7336.7041.40
SD21.2625.6516.7023.50
Mucosal 5MeTHF* (nmol/g)N727115158
Mean0.6800.6490.5430.652
CI0.557-0.8310.543-0.7780.375-0.7850.576-0.739
Plasma tHcy* (μmol/L)N707816134
Mean12.7113.2613.413.00
CI6.38-27.9812.34-14.2511.35-15.8112.14-13.28
EGRAC*N707717164
Mean1.371.371.381.37
CI1.33-1.431.34-1.411.30-1.461.35-1.39
Plasma riboflavin* (nmol/L)N717617164
Mean10.4411.3911.3910.87
CI8.80-12.409.59-13.548.14-13.479.92-12.21
Plasma FAD (nmol/L)N717517163
Mean47.6048.7753.7748.80
SD10.5811.8814.6811.72
Plasma FMN* (nmol/L)N717517163
Mean2.903.072.772.86
CI2.45-3.422.53-3.731.86-4.152.68-3.35
Plasma flavins (nmol/L)N717617164
Mean65.1567.8269.1066.80
SD19.7421.3213.7219.94
Plasma B12 (pmol/L)N78811775
Mean323341300329
SD22619983289
Whole blood SAM (μmol/L)N3534675
Mean1.721.892.791.88
SD2.683.834.343.35
Plasma pyridoxic acid (nmol/L)N2720956
Mean29.2432.7831.4330.86
SD14.8915.186.1113.88
Plasma pyridoxal phosphate (nmol/L)N2720956
Mean46.9652.8464.6951.92
SD24.6158.2435.4640.99
  • Abbreviations: tHcy, total homocysteine; FAD, flavin adenine dinucleotide; FMN, flavin mononucleotide; SAM, S-adenosyl methionine.

  • * Analysis on log-transformed data; geometric mean and 95% CI are reported.