Table 5.

RRs (95% confidence intervals) for pancreatic cancer according to quartiles of plasma insulin in HPFS, NHS and WHI cohorts

Quartiles of insulin
Ptrend
1234
Insulin (μIU/mL), median1.06.512.331.8
Cases/controls27/8532/8629/8732/85
RR (95% CI)
    Match*1.01.19 (0.65-2.21)1.06 (0.57-1.99)1.24 (0.68-2.28)0.57
    Multivariable1.01.12 (0.59-2.13)0.99 (0.51-1.91)1.08 (0.57-2.04)0.90
Excluding cases diagnosed <4 y after blood draw
    Cases/controls19/5321/5617/5514/41
    RR (95% CI)
        Match*1.01.06 (0.50-2.26)0.89 (0.40-1.95)1.02 (0.45-2.31)0.98
        Multivariable1.00.92 (0.41-2.07)0.76 (0.32-1.80)0.86 (0.36-2.09)0.77
  • * Matching factors include age, month of blood draw, smoking status, cohort. The PHS cohort is not included as fasting samples were not available on the majority of participants.

  • Additionally controlling for BMI (quartiles), physical activity (quartiles), current multivitamin use, and high smoking dose (25+ cigarettes/d).