Table 2.

Age-adjusted odds ratios (OR) and 95% confidence intervals (CI) for polymorphisms in NER pathway genes stratified by PAH-DNA adducts, Long Island breast cancer study project, 1996-1997

GenotypePAH-DNA adductsCases, NControls, NOdds Ratio* (95% CI)
ERCC1 8092C/A
    CCNon-Detectable1191511.00
    CANon-Detectable901190.95 (0.66-1.38)
    AANon-Detectable14200.89 (0.43-1.85)
    CCDetectable3403561.21 (0.91-1.61)
    CADetectable2512581.24 (0.92-1.67)
    AADetectable45301.92 (1.14-3.25)
    CCDetectable (<Median)1701841.18 (0.86-1.63)
    CADetectable (<Median)1291221.35 (0.96-1.91)
    AADetectable (<Median)26152.21 (1.12-4.38)
    CCDetectable (≥Median)1701721.24 (0.90-1.72)
    CADetectable (≥Median)1221361.14 (0.81-1.61)
    AADetectable (≥Median)19151.63 (0.79-3.36)
XPA -4G/A
    GGNon-Detectable931301.00
    GANon-Detectable1141241.32 (0.91-1.91)
    AANon-Detectable17370.70 (0.37-1.32)
    GGDetectable3082781.60 (1.17-2.19)
    GADetectable2622761.36 (0.99-1.87)
    AADetectable67871.08 (0.71-1.64)
    GGDetectable (<Median)1451341.58 (1.11-2.26)
    GADetectable (<Median)1431371.49 (1.04-2.12)
    AADetectable (<Median)40461.24 (0.75-2.05)
    GGDetectable (≥Median)1631441.62 (1.14-2.30)
    GADetectable (≥Median)1191391.23 (0.86-1.77)
    AADetectable (≥Median)27410.91 (0.52-1.58)
XPD Asp312Asn(G/A)
    GGNon-Detectable841331.00
    GANon-Detectable1111091.57 (1.07-2.30)
    AANon-Detectable20440.71 (0.39-1.29)
    GGDetectable2592791.45 (1.05-2.00)
    GADetectable2702761.56 (1.13-2.15)
    AADetectable92781.83 (1.22-2.76)
    GGDetectable (<Median)1381251.74 (1.21-2.51)
    GADetectable (<Median)1431511.53 (1.07-2.18)
    AADetectable (<Median)39401.50 (0.89-2.53)
    GGDetectable (≥Median)1211541.22 (0.84-1.75)
    GADetectable (≥Median)1271251.60 (1.10-2.31)
    AADetectable (≥Median)53382.19 (1.32-3.61)
XPF Arg415Gln(G/A)
    GGNon-Detectable1702371.00
    GA+AANon-Detectable43451.38 (0.87-2.19)
    GGDetectable5295201.44 (1.14-1.82)
    GA+AADetectable871091.13 (0.80-1.60)
    GGDetectable (<Median)2762611.51 (1.16-1.96)
    GA+AADetectable (<Median)43531.14 (0.73-1.79)
    GGDetectable (≥Median)2532591.38 (1.06-1.79)
    GA+AADetectable (≥Median)44561.12 (0.72-1.75)
XPG Asp1104His(G/C)
    GGNon-Detectable1231631.00
    GCNon-Detectable70970.98 (0.66-1.46)
    CCNon-Detectable14191.04 (0.48-2.23)
    GGDetectable3533291.46 (1.10-1.93)
    GCDetectable2182551.18 (0.88-1.59)
    CCDetectable41391.48 (0.90-2.44)
    GGDetectable (<Median)1741731.37 (1.00-1.88)
    GCDetectable (<Median)1201141.46 (1.03-2.07)
    CCDetectable (<Median)22211.44 (0.75-2.75)
    GGDetectable (≥Median)1791561.56 (1.09-2.13)
    GCDetectable (≥Median)981410.95 (0.67-1.36)
    CCDetectable (≥Median)19181.52 (0.76-3.04)
  • * Adjusted for age.

  • Referent group.