Table 1.

Genotype frequency for polymorphisms in NER pathway genes, Long Island breast cancer study project, 1996-1997

GeneGenotypeCases, N (%)Controls, N (%)Odds Ratio* (95% CI)
ERCC1CC551 (52.1)606 (54.9)1.00
CA434 (41.1)436 (39.5)1.09 (0.92-1.30)
AA72 (6.8)62 (5.6)1.29 (0.90-1.85)
XPAGG488 (46.1)488 (44.3)1.00
GA466 (44.0)477 (43.3)0.97 (0.81-1.17)
AA105 (9.9)137 (12.4)0.77 (0.58-1.02)
XPDGG (Asp/Asp)415 (40.2)490 (45.2)1.00
GA (Asp/Asn)478 (46.4)454 (41.9)1.25 (1.04-1.50)
AA (Asn/Asn)138 (13.4)139 (12.8)1.16 (0.89-1.52)
XPFGG (Arg/Arg)859 (84.4)888 (83.4)1.00
GA (Arg/Gln)156 (15.3)167 (15.7)0.99 (0.78-1.26)
AA (Gln/Gln)3 (0.3)10 (0.9)0.27 (0.07-1.00)
XPGGG (Asp/Asp)562 (56.3)571 (54.3)1.00
GC (Asp/His)371 (37.1)409 (38.9)0.94 (0.78-1.13)
CC (His/His)66 (6.6)71 (6.8)0.98 (0.69-1.41)
  • * Adjusted for age.

  • Referent group.