Table 3.

Results by period for selected energy-adjusted nutrients with and without supplements from a case-control study of medulloblastoma/PNET in children ages 0 to 6 years

NutrientPericonception
Midpregnancy
Quartile rangesCrude OR (95% CI)Adjusted* OR (95% CI)Quartile rangesCrude OR (95% CI)Adjusted* OR (95% CI)
Calcium without supplements (mg)<5371.01.0<5791.01.0
537-6271.0 (0.7-1.6)1.1 (0.6-1.8)579-6790.8 (0.5-1.3)0.9 (0.6-1.6)
628-7261.3 (0.8-2.0)1.2 (0.7-2.0)680-7921.3 (0.8-2.0)1.1 (0.6-1.8)
≥7271.1 (0.7-1.7)1.1 (0.6-1.8)≥7931.1 (0.7-1.8)1.1 (0.6-1.9)
Ptrend0.510.85Ptrend0.300.64
Calcium with supplements (mg)<5471.01.0<8041.01.0
547-6490.9 (0.6-1.4)0.9 (0.6-1.6)804-9191.1 (0.7-1.7)1.1 (0.7-1.9)
650-7691.4 (0.9-2.2)1.1 (0.6-1.8)920-1,0621.1 (0.7-1.7)0.9 (0.6-1.6)
≥7701.0 (0.6-1.6)0.9 (0.5-1.6)≥1,0631.2 (0.8-1.9)0.9 (0.6-1.6)
Ptrend0.710.80Ptrend0.420.71
Folate without supplements (μg)<2671.01.0<2791.01.0
267-3221.3 (0.8-2.0)1.1 (0.7-1.9)279-3321.2 (0.8-1.9)1.3 (0.7-2.1)
323-3791.0 (0.7-1.6)1.0 (0.6-1.7)333-4031.0 (0.7-1.6)1.0 (0.6-1.8)
≥3801.3 (0.8-2.1)1.2 (0.7-2.0)≥4041.1 (0.7-1.6)1.0 (0.6-1.6)
Ptrend0.330.65Ptrend0.840.67
Folate with supplements (μg)<2861.01.0<9611.01.0
286-3470.9 (0.6-1.5)0.9 (0.5-1.5)961-1,2760.9 (0.6-1.4)0.7 (0.4-1.1)
348-4821.1 (0.7-1.8)1.3 (0.8-2.2)1,277-1,3641.0 (0.6-1.5)0.9 (0.5-1.5)
≥4830.7 (0.5-1.1)0.5 (0.3-0.9)≥1,3651.0 (0.7-1.6)0.8 (0.5-1.3)
Ptrend0.090.007Ptrend0.950.33
Iron without supplements (mg)<121.01.0<12.01.01.0
12-13.60.9 (0.6-1.4)0.8 (0.5-1.4)12.1-14.10.9 (0.6-1.4)0.8 (0.5-1.4)
13.7-16.31.1 (0.7-1.7)1.2 (0.7-2.1)14.2-16.90.8 (0.5-1.3)1.0 (0.6-1.6)
≥16.40.8 (0.5-1.3)0.8 (0.5-1.3)≥17.00.8 (0.5-1.2)0.7 (0.4-1.2)
Ptrend0.440.44Ptrend0.260.21
Iron with supplements (mg)<12.41.01.0<681.01.0
12.4-14.80.8 (0.5-1.3)0.8 (0.5-1.4)68-750.9 (0.6-1.4)0.8 (0.5-1.4)
14.9-21.20.9 (0.6-1.4)0.8 (0.5-1.4)76-891.0 (0.7-1.6)1.0 (0.6-1.6)
≥21.30.7 (0.4-1.0)0.5 (0.3-0.9)≥900.7 (0.5-1.1)0.7 (0.4-1.1)
Ptrend0.100.008Ptrend0.150.11
Vitamin C without supplements (mg)<1251.01.0<1351.01.0
125-1690.9 (0.6-1.4)0.8 (0.4-1.3)136-1840.7 (0.4-1.0)0.6 (0.3-1.0)
170-2230.9 (0.6-1.4)0.8 (0.5-1.4)185-2400.6 (0.4-1.0)0.5 (0.3-0.9)
≥2240.9 (0.6-1.4)0.7 (0.4-1.2)≥2410.7 (0.5-1.1)0.6 (0.4-1.1)
Ptrend0.730.31Ptrend0.220.13
Vitamin C with supplements (mg)<1331.01.0<2151.01.0
134-1900.8 (0.5-1.3)0.9 (0.5-1.5)216-2660.8 (0.5-1.2)0.6 (0.3-1.0)
191-2610.9 (0.6-1.4)0.9 (0.5-1.5)267-3290.7 (0.5-1.1)0.5 (0.3-0.9)
≥2620.9 (0.6-1.4)0.9 (0.5-1.5)≥3301.0 (0.6-1.6)0.9 (0.5-1.5)
Ptrend0.920.75Ptrend0.930.71
Vitamin E without supplements (IU)<7.01.01.0<7.31.01.0
7.0-8.11.1 (0.7-1.6)1.1 (0.6-1.8)7.3-8.50.9 (0.6-1.4)0.7 (0.4-1.2)
8.2-9.51.0 (0.7-1.6)1.2 (0.7-2.0)8.6-10.10.8 (0.5-1.3)0.9 (0.5-1.5)
≥9.61.2 (0.8-1.9)1.4 (0.8-2.3)>10.11.0 (0.6-1.5)1.0 (0.6-1.6)
Ptrend0.460.21Ptrend0.980.77
Vitamin E with supplements (IU)
<7.21.01.0≤201.01.0
7.3-9.81.0 (0.6-1.5)1.2 (0.6-2.1)21-351.0 (0.6-1.5)1.1 (0.7-1.9)
9.9-13.61.1 (0.7-1.7)1.6 (0.8-3.1)36-390.7 (0.5-1.1)0.7 (0.4-1.3)
≥13.70.9 (0.6-1.5)0.9 (0.5-1.6)≥400.8 (0.5-1.3)0.8 (0.5-1.4)
Ptrend0.720.24Ptrend0.180.27
  • * Adjusted for mother's race, date of interview, child's age at interview, income, number of cigarettes smoked per day, total calories, and maternal weight gain (yes/no) because of pregnancy nausea/vomiting.

  • P < 0.05 for quartile OR.