Table 2.

Results for supplement use during pregnancy by period and pattern from a case-control study of medulloblastoma/PNET in children ages 0 to 6 years

SupplementnCrude OR (95% CI)PAdjusted* OR (95% CI)P
Multivitamin
    Any5811.3 (0.7-2.4)0.361.2 (0.6-2.4)0.66
    Period
        Conception1470.8 (0.6-1.2)0.340.7 (0.4-1.0)0.08
        Trimester 15371.0 (0.7-1.6)0.910.9 (0.5-1.6)0.80
        Trimester 25631.3 (0.8-2.2)0.341.2 (0.6-2.2)0.61
        Trimester 35511.2 (0.7-1.9)0.611.0 (0.6-1.9)0.90
    Pattern of use
        No use460.9 (0.5-1.8)0.771.2 (0.5-2.7)0.67
        Use starting close to conception (reference)1371.01.0
        Use starting in trimester 13591.2 (0.8-1.9)0.271.6 (1.0-2.5)0.05
        Use starting in trimester 2371.4 (0.7-2.9)0.381.5 (0.7-3.6)0.32
    Duration (increase of 1 mo)6171.00 (0.9-1.1)0.990.99 (0.9-1.1)0.71
Calcium
    Any960.9 (0.6-1.3)0.580.8 (0.5-1.2)0.27
    Period
        Conception520.8 (0.5-1.5)0.560.6 (0.3-1.2)0.15
        Trimester 1780.8 (0.5-1.4)0.540.8 (0.4-1.3)0.35
        Trimester 21100.8 (0.5-1.2)0.340.7 (0.4-1.1)0.10
        Trimester 31150.7 (0.5-1.1)0.150.6 (0.4-1.0)0.06
    Pattern of use
        No use (reference)4721.01.0
        Use close to conception only161.0 (0.4-2.6)0.960.6 (0.2-2.0)0.45
        Use starting close to conception290.5 (0.2-1.1)0.100.4 (0.2-1.0)0.06
        Use starting in trimester 1370.8 (0.4-1.6)0.580.9 (0.4-1.9)0.76
        Use starting in trimester 2360.9 (0.4-1.7)0.690.6 (0.3-1.2)0.14
Folic acid
    Any180.8 (0.3-2.0)0.811.1 (0.4-3.2)0.86
Iron
    Any1070.7 (0.5-1.1)0.170.9 (0.5-1.4)0.60
    Period
        Conception400.9 (0.5-1.7)0.870.8 (0.4-1.6)0.46
        Trimester 1890.8 (0.5-1.2)0.301.0 (0.6-1.8)0.96
        Trimester 21440.8 (0.5-1.1)0.180.8 (0.5-1.2)0.28
        Trimester 31410.8 (0.6-1.2)0.390.8 (0.5-1.3)0.35
    Pattern of use
        No use (reference)4461.01.0
        Use starting close to conception200.9 (0.4-2.2)0.840.6 (0.2-1.8)0.36
        Use starting in trimester 1570.8 (0.4-1.3)0.351.0 (0.5-2.1)0.90
        Use starting in trimester 2560.8 (0.5-1.4)0.410.7 (0.4-1.3)0.25
Vitamin C
    Any581.4 (0.8-2.4)0.271.4 (0.7-2.6)0.30
Vitamin E
    Any151.2 (0.4-3.2)0.801.0 (0.3-3.2)0.97
  • * Adjusted for mother's race, date of interview, child's age at interview, income, number of cigarettes smoked per day, total calories, and maternal weight gain (yes/no) because of pregnancy nausea/vomiting; the n is 572 because of missing data for income level and gained weight.

  • Use continued from the specified start of use until the end of the pregnancy unless otherwise noted.

  • The reference group for multivitamin use is the group who began use close to conception instead of those who did not use the supplement at any time during the pregnancy. For multivitamins, the small number of never users would have resulted in imprecise estimates of the OR; we chose a larger group as the reference group.