Table 3.

Risk of detection of any colorectal neoplasia by genotype and folate treatment

VariantGenotypeIntervention
Pinteraction
Folate-treated
Non-folate-treated
Colorectal neoplasia detected/not detectedRR* (95% CI)Colorectal neoplasia detected/not detectedRR* (95% CI)
MTHFR C677TCC41/87Reference25/91Reference0.30
CT23/960.71 (0.46-1.10)33/921.21 (0.80-1.85)
TT10/221.27 (0.71-2.29)5/211.03 (0.46-2.27)
CT/TT33/1180.82 (0.56-1.21)38/1131.19 (0.79-1.79)
MTHFR A1298CAA43/94Reference32/99Reference0.42
AC19/940.56 (0.35-0.88)24/900.89 (0.57-1.39)
CC12/271.00 (0.64-1.56)7/151.57 (0.83-2.96)
AC/CC31/1210.67 (0.47-0.97)31/1050.99 (0.65-1.49)
MTR A2756GAA56/135Reference45/145Reference0.75
AG17/610.74 (0.48-1.15)17/531.00 (0.64-1.57)
GG1/90.35 (0.06-2.02)1/60.45 (0.09-2.21)
AG/GG18/700.70 (0.45-1.08)18/590.94 (0.61-1.46)
MTRR A66GAA23/41Reference15/38Reference0.47
AG30/1090.53 (0.34-0.83)24/1030.80 (0.47-1.37)
GG21/550.65 (0.41-1.03)24/631.08 (0.65-1.79)
AG/GG51/1640.57 (0.38-0.86)48/1660.92 (0.58-1.47)
TSER3R/3R24/59Reference14/53Reference0.71
3R/2R31/1010.81 (0.54-1.21)32/1041.10 (0.65-1.85)
2R/2R17/431.06 (0.64-1.78)17/461.15 (0.66-2.02)
3R/2R and 2R/2R48/1440.88 (0.60-1.29)49/1501.12 (0.69-1.81)
TS high/low§High31/81Reference24/72Reference0.81
Low41/1221.03 (0.71-1.51)39/1310.89 (0.59-1.35)
TS 1494del6wt/wt39/98Reference29/106Reference0.71
wt/−6bp30/900.87 (0.59-1.28)29/891.14 (0.76-1.72)
−6bp/−6bp5/170.77 (0.35-1.69)5/91.40 (0.67-2.92)
wt/−6bp and −6bp/−6bp35/1070.86 (0.59-1.24)34/981.17 (0.79-1.74)
  • * RR and 95% CI adjusted for sex and interval between entry and follow-up colonoscopy.

  • P < 0.05.

  • P < 0.01.

  • § High and low TS expression genotypes based on TSER and TSER 3R G>C polymorphisms (high: 3RG/3RG, 3RG/3RC, 3RG/2R; low: 3RC/3RC, 3RC/2R, 2R/2R).