Table 2.

Risk of detection of any colorectal neoplasia and advanced neoplasia at follow-up colonoscopy according to folate metabolism genotypes

VariantGenotypeAny colorectal neoplasia
Advanced colorectal neoplasia*
Detected/not detectedRR (95% CI)Detected/not detectedRR (95% CI)
MTHFR A2756GCC66/178Reference34/210Reference
CT56/1880.92 (0.69-1.23)30/2141.00 (0.65-1.55)
TT15/431.18 (0.73-1.89)6/520.98 (0.43-2.25)
CT/TT71/2310.97 (0.73-1.27)36/2661.00 (0.66-1.52)
MTHFR A1298CAA75/193Reference35/233Reference
AC43/1840.71 (0.52-0.97)24/2030.85 (0.53-1.37)
CC19/321.19 (0.83-1.71)11/401.43 (0.79-2.57)
AC/CC62/2160.81 (0.62-1.06)35/2430.98 (0.64-1.49)
MTR A2756GAA101/280Reference48/333Reference
AG34/1140.88 (0.64-1.19)22/1261.19 (0.77-1.83)
GG2/150.41 (0.12-1.39)0/17
AG/GG36/1290.82 (0.61-1.12)22/1431.06 (0.68-1.64)
MTRR A66GAA38/79Reference23/94Reference
AG54/2120.64 (0.46-0.90)§26/2400.51 (0.31-0.85)§
GG45/1180.83 (0.59-1.16)21/1420.64 (0.38-1.06)
AG/GG99/3300.71 (0.53-0.96)47/3820.55 (0.36-0.86)§
TSER3R/3R38/112Reference21/129Reference
3R/2R63/2050.92 (0.67-1.27)33/2350.86 (0.53-1.40)
2R/2R34/891.08 (0.74-1.55)16/1070.90 (0.50-1.62)
3R/2R and 2R/2R97/2940.97 (0.72-1.31)49/3420.87 (0.56-1.37)
TS high/lowHigh55/153Reference29/179Reference
Low80/2530.96 (0.73-1.27)41/2920.93 (0.61-1.42)
TS 1494del6wt/wt68/204Reference36/236Reference
wt/−6bp59/1790.98 (0.74-1.31)28/2100.92 (0.59-1.43)
−6bp/−6bp10/261.03 (0.60-1.77)6/361.19 (0.60-2.37)
wt/−6bp and −6bp/−6bp69/2050.99 (0.75-1.30)34/2460.96 (0.63-1.45)
  • * Advanced colorectal neoplasia was defined as CRAs with villous or tubulovillous features, size ≥1 cm, severe dysplasia, or CRC.

  • RR and 95% CI adjusted for sex and interval between entry and follow-up colonoscopy.

  • P < 0.05.

  • § P = 0.01.

  • High and low TS expression genotypes based on TSER and TSER 3R G>C polymorphisms (high: 3RG/3RG, 3RG/3RC, 3RG/2R; low: 3RC/3RC, 3RC/2R, 2R/2R).