Table 1.

Comparison of the total UKCAP trial population and patients genotyped in this study

VariableUKCAP trial populationGenotyped patients
n853546
Age*
    Mean (y)57.557.3
    SD9.39.3
Sex
    Male477 (56%)289 (53%)
    Female376 (44%)256 (47%)
Intervention
    Folate alone215 (25.2%)144 (26.4%)
    Aspirin alone217 (25.4%)131 (24.0%)
    Folate and aspirin217 (25.4%)135 (24.7%)
    Double placebo204 (23.9%)136 (24.9%)
Colonoscopy interval
    Mean (mo)40.340.7
    Range (mo)2-796-74
Outcome
    Adenoma207 (24.2%)130 (23.8%)
    Carcinoma11 (1.3%)7 (1.3%)
    Advanced neoplasia104 (12.2%)70 (12.8%)
  • * Age at entry colonoscopy.

  • Interval between entry and follow-up colonoscopy.

  • Follow-up colonoscopy outcome definitions were adenoma, histologically confirmed CRA; carcinoma, histologically confirmed CRC; advanced neoplasia, CRA ≥1 cm diameter, villous or tubulovillous histology, severe dysplasia, or CRC.