Table 2.

Risk of invasive breast cancer among white non-Hispanic BRCA1 and BRCA2 mutation carriers according to alcohol consumption for women under 50 years of age by gene

Alcohol consumptionBRCA1 mutation carriers
BRCA2 mutation carriers
Cases* (N = 195)
Controls* (N = 302)
OR (95% CI)Cases* (N = 128)
Controls* (N = 179)
OR (95% CI)
n (%)n (%)n (%)n (%)
Ever use
    No99 (51)170 (58)1.0060 (47)86 (48)1.00
    Yes95 (49)123 (42)1.06 (0.73-1.52)68 (53)93 (52)0.66 (0.45-0.97)
Current use
    No126 (65)203 (69)1.0078 (61)125 (70)1.00
    Yes68 (35)90 (31)0.96 (0.67-1.37)50 (39)54 (30)1.11 (0.76-1.63)
Drink-years
    Nonusers99 (54)170 (60)1.0060 (49)86 (52)1.00
    1-2926 (14)38 (13)1.07 (0.64-1.76)14 (11)27 (16)0.40 (0.21-0.74)
    >2957 (31)76 (27)0.93 (0.62-1.39)49 (40)51 (31)0.89 (0.59-1.34)
Trend/ 10 drink-years0.98 (P = 0.5)1.02 (P = 0.4)
Intake/d (g)
    Nonusers99 (53)170 (58)1.0060 (47)86 (49)1.00
    1-414 (7)32 (11)0.63 (0.34-1.18)11 (9)24 (14)0.41 (0.22-0.77)
    >475 (40)91 (31)1.14 (0.77-1.69)55 (44)66 (37)0.79 (0.52-1.18)
Trend/10 g1.02 (P = 0.4)1.00 (P = 0.9)
  • * The totals for the different variables may not be equal to the total number of subjects in a category because of missing data.

  • OR, odds ratio; CI, confidence interval.

  • Stratified on age (<40 years and >40-49 years) and study sites (Australia, Canada, Utah, other U.S. states) and adjusted for age (continuous), family history (number of first-degree relatives with breast or ovarian cancer), smoking (ever and never), and number of full-term pregnancies (continuous).