Table 1.

Characteristics of non-Hispanic white BRCA mutation carriers with and without invasive breast cancer by mutation status

BRCA1 mutation carriers
BRCA2 mutation carriers
Cases* (N = 195)
Controls* (N = 302)
Cases* (N = 128)
Controls* (N = 179)
n (%)n (%)n (%)n (%)
Reference age (y)
    <3023 (12)80 (27)10 (8)34 (19)
    30-3988 (45)107 (35)61 (48)60 (34)
    40-4984 (43)115 (38)57 (44)85 (47)
Year of birth
    1940-194916 (8)30 (10)16 (13)34 (19)
    1950-1959103 (53)87 (29)61 (48)53 (30)
    1960-196965 (33)98 (32)49 (38)56 (31)
    1970+11 (6)87 (29)2 (1)36 (20)
Study site
    Australia91 (47)121 (40)65 (51)91 (51)
    Canada47 (24)15 (5)35 (27)13 (7)
    Utah15 (8)85 (28)6 (5)32 (18)
    Other U.S. states42 (21)81 (27)22 (17)43 (24)
Ascertainment
    Clinic based120 (62)284 (94)76 (59)158 (88)
    Population based75 (38)18 (6)52 (41)21 (12)
Family history114 (58)229 (76)67 (52)127 (71)
Number of full-term pregnancies
    049 (25)102 (34)27 (21)37 (21)
    1-299 (51)114 (38)64 (50)82 (46)
    >346 (24)85 (28)37 (29)60 (33)
Ever smoker93 (48)97 (33)68 (54)61 (34)
  • * The totals for the different variables may not be equal to the total number of subjects in a category because of missing data.

  • For cases, age at breast cancer diagnosis and, for controls, age at the earliest of these events: bilateral mastectomy, bilateral oophorectomy, diagnosis of in situ breast cancer, and interview.

  • Having first-degree relatives with breast cancer or ovarian cancer.