Table 6.

Association between selected characteristics and Ki-ras mutation and/or p53 overexpression

CharacteristicsKi-ras and p53-negative (n = 701)Ki-ras or p53-positive (n = 154)Ki-ras and p53-positive (n = 17)P*
Age, y (SE)66.1 (0.33)66.5 (0.60)67.8 (1.22)0.04
Male (%)67.368.469.50.75
Family history (%)18.113.49.80.11
Previous polyp (%)40.022.311.0<0.0001
No. of adenomas (SE)1.81 (0.05)1.89 (0.08)1.96 (0.17)0.40
Rectal adenomas (%)9.113.820.20.04
Size, mm (SE)7.8 (0.23)12.0 (0.41)16.2 (0.84)<0.0001
HGD (%)18.641.067.9<0.0001
Tubulovillous/villous histology (%)19.354.685.8<0.0001
Advanced adenomas (%)§44.979.594.8<0.0001
  • * χ2 for categorical variables and P trends for continuous variables (adjusted for age and number of adenomas).

  • History of colorectal cancer in one or more first-degree relatives.

  • Self-reported history of polyps prior to baseline adenoma.

  • § Includes one or more of the following characteristics: tubulovillous or villous histology, ≥1 cm in size, or HGD.