Table 5.

Association between selected characteristics and p53 overexpression

Characteristicsp53 overexpression, no. (%)No p53 overexpression, no.Unadjusted OR (95% CI)Adjusted OR (95% CI)*P
Age (y)
    ≤6021 (8.2)2341.001.000.06
    61-6720 (9.0)2021.10 (0.58-2.09)1.01 (0.49-2.10)
    68-7212 (5.7)1970.68 (0.33-1.41)0.50 (0.21-1.16)
    >7210 (4.7)2040.55 (0.25-1.19)0.51 (0.21-1.27)
Gender
    Female18 (6.2)2731.001.000.46
    Male45 (7.4)5641.21 (0.69-2.13)1.28 (0.67-2.46)
Family history
    No58 (7.8)6901.001.000.10
    Yes5 (3.3)1470.40 (0.16-1.03)0.40 (0.14-1.19)
Previous polyp
    No50 (9.7)4681.001.000.03
    Yes7 (2.3)2960.22 (0.10-0.49)0.35 (0.14-0.88)
No. of adenomas at baseline
    136 (7.1)4711.001.000.84
    214 (6.8)1930.95 (0.50-1.80)1.16 (0.56-2.42)
    >213 (7.0)1730.98 (0.51-1.90)1.05 (0.44-2.50)
Adenoma location
    Distal colon41 (9.2)4031.001.000.85
    Proximal colon10 (3.4)2800.35 (0.17-0.71)0.71 (0.29-1.78)
    Rectum6 (7.4)750.79 (0.32-1.92)0.85 (0.33-2.19)
Size (cm)
    <110 (1.8)5351.001.00<0.0001
    ≥151 (14.4)3029.03 (4.52-18.06)5.25 (2.39-11.5)
Dysplasia
    Low grade31 (4.5)6501.001.000.05
    High grade32 (15.7)1723.90 (2.32-6.57)1.88 (1.01-3.51)
Histology
    Tubular24 (3.7)6311.001.000.04
    Tubulovillous or villous39 (16.1)2035.05 (2.97-8.60)1.96 (1.03-3.71)
Advanced adenoma§
    No7 (1.6)4231.001.00<0.0001
    Yes56 (10.6)4148.17 (3.68-18.14)7.20 (3.01-17.22)
  • * Advanced adenoma ORs were adjusted for previous polyps and location. All other factors were adjusted for previous polyp, location, size, dysplasia, and histology.

  • History of colorectal cancer in one or more first-degree relatives.

  • Self-reported history of a polyp prior to baseline adenoma.

  • § Includes one or more of the following characteristics: tubulovillous or villous histology, ≥1 cm in size, or HGD.