Table 2.

Association of MDM2 SNP309 with lung cancer stratified by pack-years of smoking

GenotypeOverall*
African-Americans
Caucasians
CasesControlsOR (95% CI)CasesControlsOR (95% CI)CasesControlsOR (95% CI)
MDM2 SNP309
    ≤10 pack-yearsT/T311881.00151141.0016741.00
T/G24841.53 (0.82-2.86)6221.93 (0.67-5.61)18621.39 (0.65-2.95)
G/G9231.95 (0.79-4.84)029211.97 (0.76-5.11)
T/G + G/G331071.62 (0.90-2.91)6241.77 (0.61-5.10)27831.54 (0.77-3.09)
    11-44 pack-yearsT/T73801.0038471.0035331.00
T/G34460.83 (0.53-1.32)3120.51 (0.20-1.28)31341.05 (0.61-1.80)
G/G7120.88 (0.41-1.86)017111.10 (0.48-2.49)
T/G + G/G41580.84 (0.55-1.30)3130.49 (0.21-1.18)38551.06 (0.63-1.76)
    ≥45 pack-yearsT/T83661.0032271.0051391.00
T/G56410.82 (0.53-1.26)560.60 (0.18-1.94)51350.85 (0.54-1.35)
G/G1991.19 (0.60-2.34)121871.16 (0.58-2.32)
T/G + G/G75500.88 (0.58-1.32)680.69 (0.22-2.17)69420.91 (0.59-1.41)
  • * Adjusted for race and age.

  • Adjusted for age.