Table 1.

Association of MDM2 SNP309 and MDM2 SNP354 with lung cancer

PolymorphismGenotypeCases, n (%)Controls, n (%)OR (95% CI)
MDM2 SNP309
    Overall*T/T261 (51.8)385 (57.0)1.00
T/G187 (37.1)234 (34.6)0.93 (0.70-1.91)
G/G56 (11.1)57 (8.4)1.22 (0.78-1.91)
T/G + G/G243 (48.2)291 (43.0)0.98 (0.75-1.28)
    African-AmericansT/T111 (83.5)203 (79.6)1.00
T/G20 (15.0)47 (18.4)0.70 (0.38-1.32)
G/G2 (1.5)5 (2.0)0.52 (0.09-3.05)
T/G + G/G22 (16.5)52 (20.4)0.68 (0.37-1.25)
    CaucasiansT/T150 (40.4)182 (43.2)1.00
T/G167 (45.0)187 (44.4)1.07 (0.79-1.45)
G/G54 (14.6)52 (12.4)1.25 (0.81-1.95)
T/G + G/G221 (59.6)239 (56.8)1.11 (0.84-1.48)
MDM2 SNP354
    Overall*A/A375 (86.8)474 (87.9)1.00
A/G51 (11.8)58 (10.8)1.22 (0.80-1.86)
G/G6 (1.4)7 (1.3)1.69 (0.54-5.30)
A/G + G/G57 (13.2)65 (12.1)1.26 (0.84-1.89)
    African-AmericansA/A95 (81.2)168 (84.0)1.00
A/G18 (15.4)26 (13.0)0.99 (0.47-2.09)
G/G4 (3.4)6 (3.0)2.23 (0.54-9.26)
A/G + G/G22 (18.8)32 (16.0)1.15 (0.58-2.27)
    CaucasiansA/A280 (88.9)306 (90.3)1.00
A/G33 (10.5)32 (9.4)1.31 (0.77-2.23)
G/G2 (0.6)1 (0.3)2.58 (0.22-30.09)
A/G + G/G35 (11.1)33 (9.7)1.34 (0.80-2.27)
  • * Adjusted for age, race, and pack-years of smoking.

  • Adjusted for age and pack-years of smoking.