Table 3.

ORs and 95% CIs of 1,953 cases with colorectal cancer and corresponding 4,154 controls, according to energy-adjusted classes of flavonoids in strata of sex, age, and body mass index (Italy, 1992-1996)

OR* (95% CI)
Sex (cases:controls)
Age (cases:controls)
Body mass index, kg/m2 (cases:controls)
Male (1,125:2,073)Female (828:2,081)P<60 (780:2,323)≥60 (1,173:1,831)P<25 (890:1,907)≥25 (1,063:2,247)P
Isoflavones0.90 (0.81-1.00)0.94 (0.85-1.04)0.5450.95 (0.86-1.06)0.91 (0.83-1.00)0.4570.97 (0.88-1.07)0.90 (0.81-0.99)0.339
Anthocyanidins0.90 (0.82-0.98)0.74 (0.62-0.88)0.0480.86 (0.77-0.97)0.88 (0.80-0.98)0.7630.92 (0.82-1.04)0.85 (0.77-0.94)0.244
Flavan-3-ols1.09 (1.01-1.18)0.98 (0.90-1.07)0.0591.04 (0.95-1.13)1.06 (0.99-1.15)0.6601.09 (1.01-1.18)1.02 (0.94-1.10)0.232
Flavanones0.97 (0.86-1.11)1.00 (0.88-1.14)0.7520.96 (0.84-1.09)1.00 (0.87-1.13)0.6781.01 (0.88-1.15)0.95 (0.84-1.07)0.499
Flavones0.91 (0.82-1.01)0.92 (0.82-1.03)0.9440.88 (0.78-0.99)0.97 (0.88-1.07)0.2000.96 (0.86-1.07)0.90 (0.81-1.00)0.375
Flavonols0.88 (0.79-0.98)0.85 (0.76-0.95)0.6760.87 (0.78-0.97)0.90 (0.81-0.99)0.6780.87 (0.78-0.97)0.90 (0.82-1.00)0.500
Total flavonoids1.04 (0.94-1.15)0.93 (0.82-1.05)0.1580.97 (0.87-1.09)1.03 (0.93-1.14)0.4851.06 (0.95-1.19)0.95 (0.86-1.05)0.146
  • NOTE: ORs were estimated using multiple logistic regression models adjusted for sex, age, study center, family history of colorectal cancer, education, alcohol consumption, body mass index, occupational physical activity, and energy intake, according to the residual model.

  • * Estimated for an increment of intake equal to the difference between the upper cutpoints of 4th and the 1st quintiles.

  • P values of the χ21 test of interaction.