Table 2.

ORs and 95% CIs of 1,225 cases with colon cancer and 728 cases of rectum cancer and corresponding 4,154 controls, according to energy-adjusted classes of flavonoids (Italy, 1992-1996)

Colon
Rectum
χ21 heterogeneity*
OR 5 vs 1 quintile (95% CI)OR continuous (95% CI)OR 5 vs 1 quintile (95% CI)OR continuous (95% CI)χ2 5 vs 1 (P)χ21 continuous (P)
Isoflavones0.70 (0.56-0.87)0.88 (0.81-0.97)0.81 (0.63-1.04)0.96 (0.87-1.07)0.62 (0.432)1.75 (0.186)
Anthocyanidins0.69 (0.54-0.89)0.87 (0.79-0.96)0.64 (0.48-0.86)0.84 (0.74-0.96)0.75 (0.387)0.54 (0.462)
Flavan-3-ols1.12 (0.90-1.39)1.06 (0.98-1.13)0.81 (0.62-1.06)1.03 (0.94-1.11)4.83 (0.028)0.42 (0.517)
Flavanones1.05 (0.85-1.29)1.06 (0.95-1.18)0.86 (0.66-1.11)0.90 (0.78-1.03)1.64 (0.201)3.12 (0.077)
Flavones0.77 (0.62-0.95)0.91 (0.83-1.00)0.78 (0.61-1.00)0.92 (0.82-1.02)0.04 (0.847)2.30 (0.129)
Flavonols0.65 (0.53-0.81)0.89 (0.81-0.97)0.63 (0.48-0.83)0.81 (0.72-0.91)0.03 (0.861)1.41 (0.236)
Total flavonoids1.08 (0.87-1.34)1.04 (0.95-1.14)0.83 (0.64-1.07)0.93 (0.82-1.05)3.10 (0.079)2.53 (0.111)
  • NOTE: ORs were estimated using multiple logistic regression models adjusted for sex, age, study center, family history of colorectal cancer, education, alcohol consumption, body mass index, occupational physical activity, and energy intake, according to the residual model.

  • * Between colon and rectum.

  • Estimated for an increment of intake equal to the difference between the upper cutpoints of 4th and the 1st quintiles.