Table 1.

ORs and 95% CIs of 1,953 cases with colorectal cancer and corresponding 4,154 controls, according to energy-adjusted classes of flavonoids (Italy, 1992-1996)

Mean* (SD)Quintiles
χ2 (Ptrend)Continuous
12345
Isoflavones (μg)25.4 (15.6)
    Upper cutpoint14.419.625.233.9
    Cases448408369369359
    OR§ (95% CI)10.86 (0.72-1.02)0.79 (0.66-0.94)0.77 (0.65-0.92)0.76 (0.63-0.91)10.81 (0.001)0.92 (0.86-0.99)
Anthocyanidins (mg)20.0 (18.7)
    Upper cutpoint5.311.519.431.7
    Cases429369391364400
    OR§ (95% CI)10.81 (0.68-0.96)0.78 (0.65-0.93)0.64 (0.53-0.77)0.67 (0.54-0.82)20.02 (<0.001)0.86 (0.79-0.94)
Flavan-3-ols (mg)57.4 (54.0)
    Upper cutpoint20.834.451.788.5
    Cases378342366395472
    OR§ (95% CI)10.75 (0.63-0.91)0.75 (0.62-0.90)0.79 (0.65-0.95)0.98 (0.82-1.18)0.11 (0.736)1.04 (0.98-1.10)
Flavanones (mg)38.3 (31.8)
    Upper cutpoint12.528.735.567.0
    Cases436378399347393
    OR§ (95% CI)10.88 (0.74-1.05)0.89 (0.75-1.07)0.80 (0.67-0.96)0.96 (0.81-1.15)0.62 (0.430)0.99 (0.90-1.08)
Flavones (mg)0.5 (0.3)
    Upper cutpoint0.30.40.50.7
    Cases456388358364387
    OR§ (95% CI)10.82 (0.69-0.98)0.72 (0.61-0.86)0.76 (0.64-0.91)0.78 (0.65-0.93)8.38 (0.004)0.91 (0.85-0.99)
Flavonols (mg)21.6 (10.8)
    Upper cutpoint13.217.322.028.5
    Cases439399389390336
    OR§ (95% CI)10.80 (0.67-0.95)0.77 (0.64-0.91)0.74 (0.62-0.88)0.64 (0.54-0.77)21.09 (<0.001)0.87 (0.80-0.94)
Total flavonoids (mg)137.8 (78.9)
    Upper cutpoint75.3108.5141.6191.1
    Cases383396357373444
    OR§ (95% CI)10.90 (0.75-1.08)0.79 (0.66-0.94)0.81 (0.67-0.97)0.97 (0.81-1.16)0.45 (0.500)0.99 (0.92-1.07)
  • * Mean intake and SD among controls.

  • Each quintile included 831 ± 1 controls.

  • Estimated for an increment of intake equal to the difference between the upper cutpoints of 4th and the 1st quintiles.

  • § Adjusted for age, sex, study center, family history of colorectal cancer, education, alcohol consumption, body mass index, occupational physical activity, and energy intake, according to the residual model.

  • Reference category.