Table 4.

Characteristics of patients who developed selected subsequent primary cancers after MCC

CaseMCC
Latency (y)Subsequent cancer
Age (y)/genderSiteStageInitial therapy for MCCHistologySite*Stage
Salivary gland cancer after MCC
    177/FFaceLocalizedSurgery only0.5Mucoepidermoid tumorSublingual glandLocalized
    291/FFaceLocalizedSurgery only1.3Small cell carcinomaSubmandibular glandDistant
    384/MScalp/neckLocalizedNo treatment0.8Neuroendocrine carcinomaParotid glandLocalized
Cancers of biliary sites other than liver and gallbladder after MCC
    185/MTrunkLocalizedSurgery only3.3Adenocarcinoma, NOSExtrahepatic bile ductUnknown
    266/MTrunkLocalizedSurg/rad/chemo3.8Adenocarcinoma, NOSExtrahepatic bile ductRegional
    357/MFaceLocalizedSurgery only1.8Small cell carcinomaExtrahepatic bile ductDistant
Brain cancer after MCC
    168/MTrunkLocalizedSurgery only0.1Glioma, malignantFrontal lobeUnknown
    261/MSkin, NOSRegionalRad/chemo1.9Astrocytoma, NOSOverlapping lesion of brainUnknown
    373/MFaceUnstagedSurg/rad4.1Glioblastoma, NOSParietal lobeUnknown
NHL after MCC
    167/MScalp/neckLocalizedSurg/rad0.2Small B cell lymphocyticHead/neckLocalized
    274/MFaceUnstagedSurg/rad0.3Small B cell lymphocyticHead/neckUnknown
    373/FUpper limb/shoulderRegionalSurgery only4.3Small B cell lymphocyticMultiple regionsDistant
    459/MUpper limb/shoulderDistantSurg/chemo0.1Small B cell lymphocyticLN, NOSDistant
    577/FUpper limb/shoulderUnstagedSurgery only7.1B cell, follicularAxilla/armLocalized
    670/FFaceRegionalSurg/rad3.4Large B cell, diffuseOrbitDistant
    777/MFaceLocalizedSurgery only0.6Large B cell, diffuseInguinal region/legLocalized
    885/FUpper limb/shoulderRegionalSurg/rad3.3NHL, NOSJejunumRegional
    984/MUpper limb/shoulderLocalizedSurgery only0.9NHL, NOSAxilla/armLocalized
    1086/FFaceLocalizedSurgery only3.0NHL, NOSLN, NOSUnknown
  • Abbreviations: NOS, not otherwise specified; LN, lymph node; surg, surgery; rad, radiotherapy; chemo, chemotherapy; M, male; F, female.

  • * All cases of NHL were diagnosed in lymph nodes, except for one case in the orbit and one in the jejunum.