Table 1.

Description of 1,306 patients diagnosed with first primary MCC in 11 population-based cancer registries in the SEER Program (1986-2002)

CharacteristicNo. of patients (%)Person-years of follow-upNo. of subsequent primary cancers*SIR (95% CI)
All patients1,306 (100)4,6271221.22 (1.01-1.45)
    Male746 (57.1)2,520761.17 (0.92-1.46)
    Female560 (42.9)2,107461.31 (0.96-1.74)
Age at MCC diagnosis
    <60172 (13.2)851111.47 (0.73-2.62)
    60-69246 (18.8)1,200291.14 (0.76-1.63)
    70+888 (68.0)2,576821.22 (0.97-1.51)
Calendar year of MCC diagnosis
    1986-1994474 (36.3)2,601601.09 (0.83-1.40)
    1995-2002832 (63.7)2,025621.37 (1.05-1.76)
Anatomic site
    Head581 (44.5)1,931481.10 (0.81-1.46)
    Trunk156 (11.9)511161.44 (0.82-2.34)
    Upper limb273 (20.9)1,122261.05 (0.68-1.53)
    Lower limb215 (16.5)832211.29 (0.80-1.97)
    Other or unknown81 (6.2)231112.40 (1.20-4.29)
Stage
    Localized636 (48.7)2,450601.13 (0.86-1.46)
    Regional375 (28.7)1,243331.25 (0.86-1.75)
    Distant92 (7.0)16341.05 (0.28-2.68)
    Unstaged203 (15.5)772251.46 (0.94-2.15)
Initial treatment for MCC
    Surgery only599 (45.9)2,229641.27 (0.98-1.62)
    Any radiotherapy§549 (42.0)2,039491.15 (0.85-1.51)
    Chemotherapy/other/unspecified158 (12.1)35991.24 (0.57-2.35)
Number of patients entering follow-up interval
    <1 year1,306 (100)1,035391.71 (1.21-2.33)
    1-4 years976 (74.7)2,335551.08 (0.81-1.40)
    5-9 years351 (26.9)1,022231.06 (0.67-1.59)
    10+ years105 (8.0)23551.07 (0.34-2.50)
  • NOTE: All patients were diagnosed and reported to the SEER Program with a histologically confirmed first primary MCC of the skin (January 1, 1986-December 31, 2002). MCC was defined using the International Classification of Diseases for Oncology version 3 morphology code 8247 (21). Due to rounding, percentages in the table may not sum to totals.

  • * Numbers exclude MCC.

  • P < 0.05.

  • Includes tumors that overlap the boundaries of two or more subcategories or tumors in which the site of origin is unknown.

  • § Numbers include patients receiving radiotherapy only (414 patients, 36 subsequent cancers) and those given radiotherapy and chemotherapy (135 patients, 13 subsequent cancers).

  • Numbers include patients receiving chemotherapy only (82 patients, seven subsequent cancers) and those given other or unspecified treatment (76 patients, two subsequent cancers).