Table 2.

Age- and multivariate-adjusted hazard ratios and 95% confidence intervals of stomach cancer according to dietary folate intake based on baseline and updated average intakes in the Swedish Mammography Cohort (1987-2004)

Dietary folate intake (μg/d)
Ptrend
<203203-229230-259≥260
Baseline intake
    Cases42442941
    Person-years of follow-up229,872222,902224,672226,140
    Age-adjusted HR (95% CI)*1.00 (reference)1.14 (0.74-1.76)0.69 (0.43-1.13)0.88 (0.57-1.38)0.30
    Multivariate HR (95% CI)1.00 (reference)1.13 (0.71-1.79)0.74 (0.43-1.28)1.05 (0.60-1.87)0.87
Updated average intake
    Cases36393150
    Person-years of follow-up202,613204,503222,873273,597
    Age-adjusted HR (95% CI)*1.00 (reference)1.09 (0.69-1.73)0.78 (0.48-1.27)0.94 (0.60-1.46)0.57
    Multivariate HR (95% CI)1.00 (reference)1.14 (0.71-1.83)0.75 (0.44-1.30)1.04 (0.61-1.86)0.91
  • Abbreviations: HR, hazard ratio; 95% CI, 95% confidence interval.

  • * Hazard ratios from Cox proportional hazards models that were stratified by age in months and year of enrollment.

  • Multivariate hazard ratios from Cox proportional hazards models that were stratified by age in months and year of enrollment and adjusted for education (less than high school, high school graduate, or more than high school) and intakes of total energy (continuous), alcohol (0, 0.1-14.9, 15.0-29.9, or ≥30 g/wk), vitamin C (quartiles), β-carotene (quartiles), coffee (≤1, 2-3, or ≥4 cups/d), and tea (never/seldom, <1 cup/d, or ≥1 cup/d).

  • Stomach cancer incidence from 1987 through 1997 was related to folate intake at baseline, and the incidence from 1998 through 2004 was related to the average folate intake at baseline and in 1997.