Table 3.

Cell cycle markers and other predictors of CIN3 and invasive cancer in univariate regression analysis

MarkerCrude OR (95% CI)Significance*
MI1.342 (1.172-1.535)0.0001
AI1.431 (1.191-1.728)0.0001
Ki-67§1.056 (1.011-1.102)0.013
p21§1.023 (0.984-1.063)0.247
Cyclin A§1.042 (1.005-1.080)0.025
E2F4§0.788 (0.369-1.682)0.538
p105§1.023 (0.999-1.049)0.066
p107§0.967 (0.903-1.036)0.343
p130§1.004 (0.986-1.022)0.693
Age1.090 (1.065-1.116)0.0001
High-risk HPV2.887 (1.122-7.427)0.028
High-risk HPV viral load1.227 (1.116-1.349)0.0001
  • * Mann-Whitney U test.

  • No. mitotic figures/mm2.

  • No. apoptotic cells/mm2.

  • § Percentages of stained cells in 10 randomly selected fields (×40).

  • Measured as HCII RLU/CO index.