Table 2.

Cell cycle markers in high-grade and low-grade cervical lesions

MarkerCIN3 or cancer, OR (95% CI)Low-grade lesions, OR (95% CI)Significance*
MI9.04 (5.55-12.53)1.91 (1.41-2.40)0.0001
AI4.14 (2.44-5.84)1.44 (1.12-1.76)0.0001
Ki-67§26.70 (8.43-44.96)13.14 (10.64-15.64)0.044
p21§18.12 (8.25-27.99)11.52 (8.24-14.80)0.033
Cyclin A§30.75 (16.32-45.18)15.75 (13.79-20.39)0.021
E2F4§0.33 (0.21-0.87)0.66 (0.31-1.00)0.704
p105§62.22 (36.50-87.94)40.84 (33.84-47.84)0.061
p107§8.12 (1.85-18.10)13.65 (9.98-17.31)0.200
p130§42.50 (4.38-80.61)36.70 (28.17-45.34)0.757
  • * Mann-Whitney U test.

  • No. mitotic figures/mm2.

  • No. apoptotic cells/mm2.

  • § Percentages of stained cells in 10 randomly selected fields (×40).