Table 1.

Genes differentially expressed (P < 0.001) in primary and follow-up biopsies of celecoxib-treated patients

Genes*CloneUniGene clusterFold-difference, P/Ft
Incyte ESTIncytePD:40006482.0984.45
Collagen, type X, α 1 (Schmid metaphyseal chondrodysplasia)IncytePD:4855492Hs.1797292.0615.51
Dual adaptor of phosphotyrosine and 3-phosphoinositidesIncytePD:1304879Hs.626431.9896.56
Immunoglobulin superfamily, member 6IncytePD:522893Hs.1351941.9645.65
ATP-binding cassette, subfamily B (MDR/TAP), member 1IncytePD:1931381Hs.213301.9385.48
Homo sapiens–transcribed sequencesIncytePD:4073268Hs.1331811.8994.63
Homo sapiens–transcribed sequencesIncytePD:3846507Hs.4434751.8884.85
Heparin-binding growth factor binding proteinIncytePD:2024613Hs.16901.8854.3
Caspase-8, apoptosis-related cysteine proteaseIncytePD:2466440Hs.2434911.8844.38
Platelet-activating receptor homologueIncytePD:3879095Hs.1595451.8824
Interleukin 22 receptor, α 1IncytePD:3257185Hs.1109151.8794.58
Carbonic anhydrase IIncytePD:2101663Hs.231181.8655.75
Diacylglycerol kinase, β 90 kDaIncytePD:1213571Hs.1583181.8435.64
TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68 kDa (RNA-binding protein 56)IncytePD:19073691.8254.66
Potassium inwardly-rectifying channel, subfamily J, member 2IncytePD:630604Hs.15471.8155
Chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)IncytePD:950310Hs.1640211.7696.44
Homo sapiens–transcribed sequencesIncytePD:2289203Hs.491321.7643.98
Homo sapiens mRNA; cDNA DKFZp686H0155 (from clone DKFZp686H0155)IncytePD:2906194Hs.5133021.7475.46
Keratin, hair, acidic, 3BIncytePD:3187903Hs.329501.7414.68
Down syndrome cell adhesion moleculeIncytePD:4774130Hs.490021.7394.53
Interleukin 9 receptorIncytePD:22117211.7314.82
Progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial α-2-globulin, α uterine protein)IncytePD:1976179Hs.822691.7284.09
AgrinIncytePD:4610962Hs.2733301.714.19
Homo sapiens mRNA; cDNA DKFZp686P24244 (from clone DKFZp686P24244)IncytePD:1638327Hs.1190651.6655.38
Prostaglandin I2 (prostacyclin) receptor (IP)IncytePD:663798Hs.4583241.6524.43
Retinoic acid receptor responder (tazarotene induced) 3IncytePD:1927347Hs.174661.6474.29
AdlicanIncytePD:1402105Hs.721571.6184.45
KH-type splicing regulatory protein (FUSE binding protein 2)IncytePD:3460518Hs.911421.6123.89
Small inducible cytokine subfamily C, member 1 (lymphotactin)IncytePD:3088961.65.03
Hypothetical protein LOC89958IncytePD:2238576Hs.193221.5954.5
Ras homologue gene family, member F (in filopodia)IncytePD:1905723Hs.5126181.5945.98
Purinergic receptor P2Y, G-protein coupled, 1IncytePD:1961218Hs.24111.5864.24
Copine VI (neuronal)IncytePD:2284107Hs.61321.5854.3
Unc-5 homologue C (Caenorhabditis elegans)IncytePD:3350064Hs.1256051.5824.21
Spectrin, β, erythrocytic (includes spherocytosis, clinical type I)IncytePD:2189383Hs.4385141.5744.45
Hypothetical protein DKFZp667E0512IncytePD:1214652Hs.4329981.5634.97
Homo sapiens mRNA; cDNA DKFZp564B076 (from clone DKFZp564B076)IncytePD:767447Hs.211031.563.95
DNA segment on chromosome 6 (unique) 49 expressed sequenceIncytePD:21028811.5364.63
Incyte ESTIncytePD:6372901.5293.91
Retinoic acid induced 3IncytePD:899118Hs.1946911.5033.89
Protein phosphatase 1, regulatory (inhibitor) subunit 16BIncytePD:1678639Hs.457191.5014.36
Homo sapiens–transcribed sequencesIncytePD:2344817Hs.4449481.4894.04
TUWD12IncytePD:2815133Hs.251301.4824.17
Solute carrier family 38, member 4IncytePD:778212Hs.1656551.4726.44
Incyte ESTIncytePD:16074711.4714.06
Src homology 2 domain-containing transforming protein DIncytePD:1738134Hs.74231.4554.54
Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3IncytePD:3033662Hs.2904041.4546.57
Glia maturation factor, γIncytePD:409089Hs.52101.4534.08
Inducible T-cell costimulator ligandIncytePD:2758733Hs.141551.4474.32
Zinc finger protein 205IncytePD:3315208Hs.131281.4345.45
Incyte ESTIncytePD:42919821.4233.98
pancreatic polypeptideIncytePD:254890Hs.1846041.414.2
cholinergic receptor, nicotinic, β polypeptide 3IncytePD:4337986Hs.960941.3985.54
CLIP-170-related proteinIncytePD:2290302Hs.73571.3914.65
Zeta-chain (TCR) associated protein kinase 70 kDaIncytePD:3287090Hs.2345691.3863.85
Incyte ESTIncytePD:4763481.384.75
ATP-binding cassette, subfamily C (CFTR/MRP), member 6IncytePD:18303411.373.95
GranulysinIncytePD:1878545Hs.1058061.3654.62
Proteasome (prosome, macropain) subunit, β type, 9 (large multifunctional protease 2)IncytePD:2018222Hs.3810811.354.15
Bone morphogenetic protein 7 (osteogenic protein 1)IncytePD:2187660Hs.1701951.3423.99
Potassium large conductance calcium-activated channel, subfamily M β member 3IncytePD:2288482Hs.1209051.3354.91
Thyroid hormone receptor interactor 8IncytePD:4003794Hs.4426751.3354.01
Prospero-related homeobox 1IncytePD:1680706Hs.1594371.3345.02
G protein pathway suppressor 2IncytePD:606083Hs.4382191.3255.71
RAB9A, member RAS oncogene familyIncytePD:1746329Hs.4443271.3243.89
KIAA1145 proteinIncytePD:1477151Hs.1733921.3193.78
Troponin C2, fastIncytePD:1928824Hs.1824211.3194.25
Homo sapiens–transcribed sequencesIncytePD:2959963Hs.1899551.3194.77
Hepatitis B virus x associated proteinIncytePD:829521Hs.205091.3144.93
Heparan sulfate (glucosamine) 3-O-sulfotransferase 1IncytePD:513943Hs.409681.3034.38
N-myc downstream regulated gene 1IncytePD:2055569Hs.3185671.2964.01
Homo sapiens–transcribed sequence with strong similarity to protein sp:P43897 (H. sapiens) EFTS_HUMAN Elongation factor Ts, mitochondrial precursor (EF-Ts) (EF-TsMt)IncytePD:2948353Hs.3409591.2924.54
Homo sapiens mRNA; cDNA DKFZp667O0320 (from clone DKFZp667O0320)IncytePD:1362601Hs.1375871.294.63
Platelet-derived growth factor α polypeptideIncytePD:2158373Hs.3760321.2743.75
Homo sapiens–transcribed sequencesIncytePD:694279Hs.3568121.2593.77
Hermansky-Pudlak syndrome-6 proteinIncytePD:1738248Hs.1251331.2453.85
Homo sapiens–transcribed sequence with moderate similarity to protein sp:P39192 (H. sapiens) ALU5_HUMAN Alu subfamily SC sequence contamination warning entryIncytePD:1349433Hs.1210701.2414.57
Homo sapiens cDNA: FLJ21513 fis, clone COL05778IncytePD:232715Hs.145551.224.67
Geranylgeranyl diphosphate synthase 1IncytePD:221039Hs.554981.2173.91
Homo sapiens clone 24889 mRNA sequenceIncytePD:1984908Hs.1523351.213.88
Homo sapiens transcribed sequence with weak similarity to protein ref: NP_060265.1 (H. sapiens) hypothetical protein FLJ20378 [Homo sapiens]IncytePD:2504786Hs.5135211.1793.85
Homo sapiens transcribed sequence with weak similarity to protein ref: NP_079370.1 (H. sapiens) hypothetical protein FLJ22184 [Homo sapiens]IncytePD:1451756Hs.232720.862−3.75
Zinc finger protein 263IncytePD:2816931Hs.1245530.861−3.76
BCL2/adenovirus E1B 19 kDa interacting protein 1IncytePD:4069979Hs.1457260.86−3.8
Vesicle-associated membrane protein 4IncytePD:3038946Hs.66510.854−3.91
Zinc finger protein 512IncytePD:2292949Hs.2941220.841−3.98
Ubiquitin-activating enzyme E1C (UBA3 homologue, yeast)IncytePD:3010845Hs.1543200.84−3.78
Zinc finger protein 398IncytePD:1382325Hs.1694520.839−3.84
Chromosome 2 open reading frame 3IncytePD:2779394Hs.1589690.839−4.15
Nuclear cap binding protein 1, 80 kDaIncytePD:9994240.836−3.84
2,3-bisphosphoglycerate mutaseIncytePD:2287957Hs.1983650.828−5.02
Kinetochore associated 1IncytePD:789903Hs.3005590.827−4.09
Membrane component, chromosome 11, surface marker 1IncytePD:827257Hs.2786720.826−3.88
Syntaxin 6IncytePD:2748585Hs.1571440.825−5.37
Karyopherin α 1 (importin α 5)IncytePD:465152Hs.1610080.824−4
Hypothetical protein similar to RNA-binding protein larkIncytePD:1793670Hs.499940.821−4.1
Eukaryotic translation initiation factor 4BIncytePD:1663283Hs.933790.821−4.71
5-methyltetrahydrofolate-homocysteine methyltransferase reductaseIncytePD:2593323Hs.1537920.82−4.44
Poly(A) binding protein interacting protein 1IncytePD:2360751Hs.3746140.815−3.86
Ash2 (absent, small, or homeotic)-like (Drosophila)IncytePD:2635641Hs.68560.814−3.82
Tousled-like kinase 1IncytePD:664380Hs.3692800.813−3.79
Zinc finger protein 262IncytePD:3409136Hs.1503900.81−3.94
Cerebral cavernous malformations 1IncytePD:2779795Hs.4388330.81−3.86
Bone morphogenetic protein receptor, type II (serine/threonine kinase)IncytePD:2967280Hs.532500.807−4.76
Hypothetical protein FLJ22002IncytePD:2547084Hs.4614850.804−3.84
Solute carrier family 33 (acetyl-CoA transporter), member 1IncytePD:2842553Hs.2851760.801−4.27
Hypothetical protein MGC23401IncytePD:2884394Hs.4350480.797−4.17
MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)IncytePD:2722916Hs.779550.796−4.19
Myotubularin related protein 4IncytePD:2890336Hs.1417270.796−4.43
Zinc finger protein 451IncytePD:1812489Hs.1886620.796−3.83
Osmosis responsive factorIncytePD:2078614Hs.2808110.794−3.84
Incyte ESTIncytePD:24778540.793−4.2
KIAA0725 proteinIncytePD:1824577Hs.4349660.793−5.54
Laminin, α 2 (merosin, congenital muscular dystrophy)IncytePD:2187108Hs.4451200.792−4.01
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150 kDaIncytePD:998069Hs.1227520.79−4.73
Minichromosome maintenance deficient (Saccarhomyces cerevisiae) 4IncytePD:1036690.788−3.81
Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), α 1IncytePD:1794012Hs.1283120.785−5.45
KIAA0643 proteinIncytePD:1981939Hs.1559950.784−5.83
Cohen syndrome 1IncytePD:2201626Hs.1855850.783−3.79
DKFZP434D193 proteinIncytePD:1425925Hs.191500.782−3.75
Transcriptional adaptor 2 (ADA2 homologue, yeast)-likeIncytePD:2045628Hs.1251560.781−3.88
Hypothetical protein FLJ12085IncytePD:3737086Hs.3104220.78−4.97
Vacuolar protein sorting 45A (yeast)IncytePD:2821078Hs.1342310.78−5.04
Replication factor C (activator 1) 5, 36.5 kDaIncytePD:3590056Hs.4432270.777−4.25
Solute carrier family 30 (zinc transporter), member 4IncytePD:3350921Hs.1122820.773−4.64
Zinc finger protein 450IncytePD:2808265Hs.4098760.771−3.92
Dmx-like 1IncytePD:3272587Hs.1810420.769−4.53
Inhibitor of DNA binding 4, dominant negative helix-loop-helix proteinIncytePD:23743660.768−3.8
Phosphoinositide-3-kinase, catalytic, β polypeptideIncytePD:267803Hs.2398180.767−3.76
Homo sapiens, clone IMAGE:5268696, mRNAIncytePD:2396760Hs.902860.763−3.89
3-hydroxyisobutyryl-Coenzyme A hydrolaseIncytePD:3254666Hs.2366420.761−5.34
KIAA0373 gene productIncytePD:2069349Hs.1504440.76−4.32
Acyl-Coenzyme A binding domain containing 3IncytePD:2071833Hs.68310.758−3.89
Itchy homologue E3 ubiquitin protein ligase (mouse)IncytePD:2383269Hs.3146760.755−4.05
TranslinIncytePD:986855Hs.750660.755−3.8
Golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1IncytePD:1506093Hs.4450830.754−4.77
Protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)IncytePD:2726895Hs.835720.752−4.05
Eukaryotic translation initiation factor 2, subunit 1 α, 35 kDaIncytePD:1224219Hs.1517770.751−3.82
Optic atrophy 1 (autosomal dominant)IncytePD:3140082Hs.1312730.751−4.12
Ubiquitination factor E4A (UFD2 homologue, yeast)IncytePD:4215584Hs.752750.749−3.79
Nucleoporin 153 kDaIncytePD:341994Hs.1464490.748−4.6
Adenosine deaminase, tRNA-specific 1IncytePD:3836721Hs.1886610.744−4.12
Myosin, light polypeptide 1, alkali; skeletal, fastIncytePD:973629Hs.1873380.743−3.99
Thyroid autoantigen 70 kDa (Ku antigen)IncytePD:3773032Hs.1697440.742−4.02
Origin recognition complex, subunit 3-like (yeast)IncytePD:822017Hs.3124190.741−3.84
CGI-85 proteinIncytePD:2603232Hs.4426300.74−4.08
Phosphatidylinositol-4-phosphate 5-kinase, type II, βIncytePD:1315666Hs.2910700.738−5.06
Alkylglycerone phosphate synthaseIncytePD:334227Hs.4079330.734−4.54
Transmembrane 9 superfamily protein member 4IncytePD:2372824Hs.793050.73−4.56
Homo sapiens transcribed sequence with moderate similarity to protein ref: NP_004563.1 (H. sapiens) plakophilin 2 [Homo sapiens]IncytePD:1873338Hs.4363790.726−4.21
DKFZP434C212 proteinIncytePD:1282176Hs.2872660.724−3.98
Hypothetical protein BC005868IncytePD:2046989Hs.1848460.722−4.77
Zinc finger and BTB domain containing 5IncytePD:736418Hs.36820.718−4.47
Soc-2 suppressor of clear homologue (Caenorhabditis elegans)IncytePD:3597760Hs.1043150.717−4.59
Adaptor-related protein complex 3, mu 2 subunitIncytePD:2135517Hs.777700.715−4.69
Ubiquitin-conjugating enzyme E2H (UBC8 homologue, yeast)IncytePD:2275196Hs.3727580.715−3.96
v-yes-1 Yamaguchi sarcoma viral oncogene homologue 1IncytePD:1887736Hs.1941480.703−4.61
RAP1, GTPase activating protein 1IncytePD:1439934Hs.4337970.698−3.82
Zinc finger protein 175IncytePD:1306335Hs.1190140.695−4.33
Implantation-associated proteinIncytePD:876466Hs.3235620.694−3.75
Homo sapiens–transcribed sequencesIncytePD:3220149Hs.303850.69−4.53
NicastrinIncytePD:2471087Hs.47880.686−3.89
Hypothetical protein MGC3067IncytePD:1879888Hs.2415760.68−4.75
Coatomer protein complex, subunit αIncytePD:3296228Hs.4771320.672−4.27
U2-associated SR140 proteinIncytePD:3179051Hs.3709070.67−4.7
Chromosome 20 open reading frame 194IncytePD:2956129Hs.1190210.667−3.83
Catenin (cadherin-associated protein), delta 1IncytePD:1976602Hs.1660110.665−4.87
KIAA1210 proteinIncytePD:3355572Hs.975940.655−3.93
Phosphoserine aminotransferase 1IncytePD:2825369Hs.2860490.619−4.54
Nuclear receptor interacting protein 1IncytePD:2366468Hs.1550170.605−4.15
BasonuclinIncytePD:3564654Hs.640250.588−3.84
Myosin, heavy polypeptide 11, smooth muscleIncytePD:1866751Hs.783440.579−4.32
Synaptonemal complex protein 2IncytePD:1692253Hs.2026760.568−4.74
  • * Genes are sorted by P/F ratio.

  • P/F, geometric mean of ratios of gene expression in primary to follow-up biopsies.