Table 3.

Gene Ontology categories from skin lesion and nonlesion comparison

GO ClassificationNo. genesFisher statistic permutation PKolmogorov-Smirnov permutation P
RNA splicing via transesterification reactions540.000010.00050
RNA splicing via transesterification reactions with bulged adenosine as nucleophile540.000010.00050
Nuclear mRNA splicing via spliceosome540.000010.00050
RNA splicing750.000010.00009
mRNA metabolism880.000090.00001
Ubiquitin thiolesterase activity210.000100.00067
Ubiquitin-specific protease activity210.000100.00067
Thiolester hydrolase activity210.000100.00067
mRNA processing780.000100.00013
Ribonucleoprotein complex890.001720.00009
tRNA modification110.001960.03898
Translation470.003000.08347
Ubiquitin-dependent protein catabolism380.003090.00065
Modification-dependent protein catabolism380.003090.00065
tRNA aminoacylation for protein translation100.003160.07688
Amino acid activation100.003160.07688
tRNA aminoacylation100.003160.07688
RNA modification160.004390.04396
Hexose transport90.006560.00010
Monosaccharide transport90.006560.00010
Glucose transport90.006560.00010
P-P-bond hydrolysis-driven transporter activity60.008160.00279
RNA localization90.009170.00485
RNA-nucleus export90.009170.00485
mRNA-nucleus export90.009170.00485
Nucleic acid transport90.009170.00485
RNA transport90.009170.00485
mRNA transport90.009170.00485
Establishment of RNA localization90.009170.00485
Nucleolus260.023190.00363
Protein amino acid glycosylation220.027780.00144
Glycoprotein metabolism250.035260.00422
Spliceosome complex230.050390.00039
Protein folding660.056080.00283
O-linked glycosylation60.071420.00371
Carrier activity450.086730.00482
Cyclic nucleotide phosphodiesterase activity110.092730.00320
Glycerophosphoinositol inositolphosphodiesterase activity110.092730.00320
Ubiquitin ligase complex830.098140.00134
Phosphoric diester hydrolase activity130.140500.00118
Unfolded protein binding310.156270.00389