Table 3.

Matched ORs (95% CIs) for association of gastric cancer with CagA strains and pepsinogen index alone and in combination with H. pylori IgG

No. cases/controlsAdjusted OR* (95% CI)PAF (95% CI), %
CagA status
    CagA (−)121/1531.0
    CagA (+)390/3581.5 (1.1-2.1)
H. pylori (IgG) and CagA combined
    IgG (−) and CagA (−)6/511.0
    IgG (−) and CagA (+)27/773.2 (1.1-9.0)3.6 (1.1-6.1)
    IgG (+)478/38311.4 (4.4-29.2)
        IgG (+) and CagA (−)115/1029.5 (3.6-25.0)20.1 (15.7-24.4)
        IgG (+) and CagA (+)363/28112.5 (4.8-32.5)65.4 (57.5-71.8)
    IgG (+) and/or CagA (+)505/46010.2 (4.0-25.9)89.1 (73.4-95.6)
Pepsinogen status
    Pepsinogen index (−)92/2161.0
    Pepsinogen index (+)21/183.2 (1.5-7.0)
    Pepsinogen index (2+)171/1413.3 (2.2-4.8)
    Pepsinogen index (3+)227/1364.6 (3.1-6.9)
    Pepsinogen index (+, ∼3+)419/2953.8 (2.7-5.4)
H. pylori (IgG) and pepsinogen index combined
    IgG (−) and pepsinogen index (−)16/1081.0
    IgG (−) and pepsinogen index (+, ∼3+)17/204.9 (2.0-12.1)2.6 (1.0-4.3)
    IgG (+)478/3837.9 (4.5-14.0)
        IgG (+) and pepsinogen index (−)76/1084.2 (2.2-8.0)11.3 (7.4-15.1)
        IgG (+) and pepsinogen index (+, ∼3+)402/27510.1 (5.6-18.2)70.9 (63.6-76.7)
    IgG (+) and/or pepsinogen index (+, ∼3+)495/4037.6 (4.3-13.4)84.1 (73.1-90.6)
  • NOTE: Pepsinogen index (−), pepsinogen I >70 or pepsinogen I/II ratio >3; (+), pepsinogen I ≤70 and pepsinogen I/II ratio ≤3, excluding pepsinogen index 2+ and 3+; (2+), pepsinogen I ≤50 and pepsinogen I/II ratio ≤3, excluding pepsinogen index 3+; (3+), pepsinogen I ≤30 and pepsinogen I/II ratio ≤2.

  • * See footnote in Table 2.

  • Ptrend < 0.0001.