Stratified analyses between the combined ERCC2 and ERCC3 genotypes and lung cancer risk in a Chinese population
| ERCC2 and ERCC3 combined genotypes | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases (n = 847), n (%) | Controls (n = 899), n (%) | Adjusted OR (95% CI)* | ||||||||||
| 0-1 at-risk locus | ≥2 at-risk loci | 0-1 at-risk locus | ≥2 at-risk loci | 0-1 at-risk locus | ≥2 at-risk loci | |||||||
| Total | 136 (16.1) | 711 (83.9) | 186 (20.7) | 713 (79.3) | 1.00 | 1.36 (1.06-1.75) | ||||||
| Age (y) | ||||||||||||
| ≤60 | 60 (14.9) | 344 (85.2) | 91 (21.0) | 342 (79.0) | 1.00 | 1.58 (1.10-2.28) | ||||||
| >60 | 76 (17.2) | 367 (82.8) | 95 (20.4) | 371 (79.6) | 1.00 | 1.19 (0.84-1.68) | ||||||
| Sex | ||||||||||||
| Male | 103 (15.5) | 560 (84.5) | 138 (20.9) | 522 (79.1) | 1.00 | 1.45 (1.09-1.95) | ||||||
| Female | 33 (17.9) | 151 (82.1) | 48 (20.1) | 191 (79.9) | 1.00 | 1.10 (0.67-1.80) | ||||||
| Smoking status | ||||||||||||
| Current smokers | 59 (17.5) | 278 (82.5) | 73 (22.7) | 249 (77.3) | 1.00 | 1.41 (0.96-2.08) | ||||||
| Former smokers | 37 (14.6) | 217 (85.4) | 27 (18.6) | 118 (81.4) | 1.00 | 1.37 (0.79-2.38) | ||||||
| Nonsmokers | 40 (15.6) | 216 (84.4) | 86 (19.9) | 346 (80.1) | 1.00 | 1.24 (0.82-1.89) | ||||||
| Family history of cancer | ||||||||||||
| No | 115 (16.5) | 582 (83.5) | 159 (20.3) | 623 (79.7) | 1.00 | 1.28 (0.98-1.68) | ||||||
| Yes | 21 (14.0) | 129 (86.0) | 27 (23.1) | 90 (76.9) | 1.00 | 1.91 (0.98-3.74) | ||||||
| Histologic types | ||||||||||||
| Adenocarcinomas | 51 (13.8) | 319 (86.2) | 1.00 | 1.61 (1.14-2.26) | ||||||||
| Squamous cell | 51 (17.8) | 236 (82.2) | 1.00 | 1.22 (0.85-1.75) | ||||||||
| Small cell | 9 (16.4) | 46 (83.6) | 1.00 | 1.40 (0.67-2.94) | ||||||||
| Other carcinomas † | 25 (18.5) | 110 (81.5) | 186 (20.7) | 713 (79.3) | 1.00 | 1.10 (0.41-1.97) | ||||||