Table 3.

Stratified analyses between the combined ERCC2 and ERCC3 genotypes and lung cancer risk in a Chinese population

ERCC2 and ERCC3 combined genotypes
Cases (n = 847), n (%)
Controls (n = 899), n (%)
Adjusted OR (95% CI)*
0-1 at-risk locus≥2 at-risk loci0-1 at-risk locus≥2 at-risk loci0-1 at-risk locus≥2 at-risk loci
Total136 (16.1)711 (83.9)186 (20.7)713 (79.3)1.001.36 (1.06-1.75)
Age (y)
    ≤6060 (14.9)344 (85.2)91 (21.0)342 (79.0)1.001.58 (1.10-2.28)
    >6076 (17.2)367 (82.8)95 (20.4)371 (79.6)1.001.19 (0.84-1.68)
Sex
    Male103 (15.5)560 (84.5)138 (20.9)522 (79.1)1.001.45 (1.09-1.95)
    Female33 (17.9)151 (82.1)48 (20.1)191 (79.9)1.001.10 (0.67-1.80)
Smoking status
    Current smokers59 (17.5)278 (82.5)73 (22.7)249 (77.3)1.001.41 (0.96-2.08)
    Former smokers37 (14.6)217 (85.4)27 (18.6)118 (81.4)1.001.37 (0.79-2.38)
    Nonsmokers40 (15.6)216 (84.4)86 (19.9)346 (80.1)1.001.24 (0.82-1.89)
Family history of cancer
    No115 (16.5)582 (83.5)159 (20.3)623 (79.7)1.001.28 (0.98-1.68)
    Yes21 (14.0)129 (86.0)27 (23.1)90 (76.9)1.001.91 (0.98-3.74)
Histologic types
    Adenocarcinomas51 (13.8)319 (86.2)1.001.61 (1.14-2.26)
    Squamous cell51 (17.8)236 (82.2)1.001.22 (0.85-1.75)
    Small cell9 (16.4)46 (83.6)1.001.40 (0.67-2.94)
Other carcinomas 25 (18.5)110 (81.5)186 (20.7)713 (79.3)1.001.10 (0.41-1.97)
  • * Adjusted for age, sex, family history of cancer, and pack-years of smoking.

  • Other carcinomas means the large cell, mixed cell carcinomas or undifferentiated carcinoma.