Table 2.

ERCC2 and ERCC3 polymorphisms and lung cancer risk in a Chinese population

GenotypeCases, n (%)Controls, n (%)Adjusted OR (95% CI)*
ERCC2 rs1618536975985
    AA177 (18.2)199 (20.2)1.00
    AG492 (50.5)488 (49.5)1.10 (0.86-1.40)
    GG306 (31.4)298 (30.3)1.15 (0.89-1.51)
    AG/AA798 (81.9)786 (79.8)1.12 (0.89-1.41)
ERCC2 rs1799786965986
    CC844 (87.5)877 (89.0)1.00
    CT117 (12.1)108 (11.0)1.12 (0.84-1.49)
    TT4 (0.4)1 (0.1)6.18 (0.68-56.52)
    CT/TT121 (12.5)109 (11.1)1.16 (0.87-1.54)
ERCC2 rs1799793970986
    GG850 (87.6)874 (88.6)1.00
    AG116 (12.0)111 (11.3)1.06 (0.80-1.41)
    AA4 (0.4)1 (0.1)6.13 (0.67-56.11)
    AG/AA120 (12.4)112 (11.4)1.10 (0.83-1.46)
ERCC2 rs3916823986987
    AAAA/AAAA744 (75.5)750 (76.0)1.00
    AAAA/−225 (22.8)227 (23.0)1.01 (0.81-1.25)
    −/−17 (1.7)10 (1.0)1.88 (0.84-4.21)
    AAAA/− + −/−242 (24.5)237 (24.0)1.04 (0.84-1.29)
ERCC2 rs13181975997
    AA827 (84.8)865 (86.8)1.00
    AC141 (14.5)127 (12.7)1.16 (0.89-1.51)
    CC7 (0.7)5 (0.5)1.64 (0.50-5.36)
    AC/CC148 (15.2)132 (13.2)1.18 (0.91-1.53)
ERCC3 rs22710261,0021,000
    TT774 (77.3)787 (78.7)1.00
    CT214 (21.4)200 (20.0)1.07 (0.86-1.34)
    CC14 (1.4)13 (1.3)1.02 (0.46-2.24)
    CT/CC228 (22.8)213 (21.3)1.07 (0.86-1.33)
ERCC3 rs4150441952975
    AA149 (15.7)178 (18.2)1.00
    AG474 (49.8)475 (48.8)1.20 (0.93-1.56)
    GG329 (34.6)322 (33.1)1.28 (0.97-1.69)
    AG/GG803 (84.4)797 (81.9)1.24 (0.97-1.58)
Combined genotypes847899
    0-1 at-risk locus136 (16.1)186 (20.7)1.00
    2 at-risk loci331 (39.1)349 (38.8)1.29 (0.98-1.70)
    3 at-risk loci231 (27.3)230 (25.6)1.38 (1.02-1.85)
    ≥4 at-risk loci149 (17.6)134 (14.9)1.51 (1.09-2.10)
Ptrend = 0.02
  • * Adjusted for age, sex, pack-years of smoking, and family history of cancer.