Table 3.

Prostate cancer and high-grade disease ORs by serum adipokines tertiles from the SABOR cohort

Prostate cancer risk,* ORs (95% CI)PtrendHigh-grade disease, ORs (95% CI)Ptrend
Adiponectin tertile
    Matched/age-adjusted analysis
        Tertile 11.00 (referent)1.00 (referent)
        Tertile 20.83 (0.43-1.58)1.48 (0.57-3.82)
        Tertile 30.87 (0.46-1.65)0.241.93 (0.74-5.10)0.30
    Multivariable adjusted
        Tertile 11.00 (referent)1.00 (referent)
        Tertile 20.80 (0.33-1.97)1.17 (0.41-3.33)
        Tertile 30.81 (0.34-1.91)0.441.45 (0.55-3.32)0.49
Leptin tertile
    Matched/age-adjusted analysis
        Tertile 11.00 (referent)1.00 (referent)
        Tertile 20.50 (0.26-0.97)0.571.26 (0.48-3.31)0.85
        Tertile 30.77 (0.43-1.37)1.20 (0.48-3.01)
    Multivariable adjusted
        Tertile 11.00 (referent)1.00 (referent)
        Tertile 20.51 (0.19-1.27)1.24 (0.44-3.50)
        Tertile 31.28 (0.57-2.88)0.351.12 (0.43-2.97)0.83
IL-6 tertile
    Matched/age-adjusted analysis
        Tertile 11.00 (referent)1.00 (referent)
        Tertile 21.09 (0.61-1.93)1.82 (0.75-4.44)
        Tertile 30.84 (0.46-1.53)0.980.84 (0.30-2.33)0.17
    Multivariable adjusted
        Tertile 11.00 (referent)1.00 (referent)
        Tertile 21.63 (0.75-3.65)0.631.35 (0.52-3.52)0.52
        Tertile 30.93 (0.42-2.06)0.85 (0.29-2.47)
  • * Estimated from conditional logistic regression models that took into account the matching factor age and adjusted for race/ethnicity.

  • Compared with low-grade prostate cancer and estimated from unconditional logistic regression models adjusting for age and race/ethnicity.