Table 7.

Association between biochemical phenotypes of p53 changes detected in benign breast tissue and risk of breast cancer

p53 ChangeNo. cases*No. controlsUnadjusted OR (95% CI)Adjusted OR (95% CI)
Wild-type4619011
All changes other than missense mutations10381.29 (0.56-2.96)1.03 (0.42-2.55)
Missense mutations outside the conserved, DNA contact, and zinc-binding domains22761.42 (0.75-2.68)1.52 (0.78-2.97)
Missense mutations inside the conserved, DNA contact, or zinc-binding domains but excluding the gene portion that encodes amino acids involved in DNA contact or zinc binding4220.88 (0.28-2.79)0.70 (0.20-2.46)
Missense mutations in amino acids directly involved in DNA contact or zinc binding01§§
  • * Unmatched distributions (matched ORs cannot be calculated directly from these numbers).

  • Adjusted for age at menarche, age at first live birth, menopausal status, Quetelet's index, family history of breast cancer in a first-degree relative, and epithelial hyperplasia.

  • Reference category.

  • § Not estimated.