Table 6.

Risk of breast cancer in association with mutations detected in benign breast tissue in functional domains of the p53 gene

p53 ChangeNo. cases*No. controlsUnadjusted OR (95% CI)Adjusted OR (95% CI)
Wild-type4619011
Changes other than those in functional domains17581.40 (0.70-2.82)1.46 (0.70-3.06)
NH2-terminal transcriptional activation domain (1-44)§03
Proline-rich regulatory domain (62-94)7301.14 (0.45-2.89)0.88 (0.32-2.43)
DNA-binding domain (110-292)8371.15 (0.48-2.76)1.05 (0.41-2.66)
Oligomerization domain (325-363)251.68 (0.30-9.60)1.81 (0.27-11.94)
COOH-terminal domain (363-393)242.54 (0.40-16.23)1.95 (0.23-16.55)
  • * Unmatched distributions (matched ORs cannot be calculated directly from these numbers).

  • Adjusted for age at menarche, age at first live birth, menopausal status, Quetelet's index, family history of breast cancer in a first-degree relative, and epithelial hyperplasia.

  • Reference category.

  • § Residues.

  • Not estimated.