Table 4.

Risk of breast cancer in association with mutations detected in benign breast tissue in conserved domains of the p53 gene

Location of p53 mutationNo. cases*No. controlsUnadjusted OR (95% CI)Adjusted OR (95% CI)
Wild-type4619011
Mutation outside conserved domains311191.31 (0.73-2.32)1.31 (0.71-2.40)
Domain II§251.67 (0.31-9.05)1.12 (0.17-7.52)
Domain III251.91 (0.33-11.19)1.75 (0.26-11.76)
Domain IV170.68 (0.07-6.46)0.43 (0.04-4.67)
Domain V01
  • * Unmatched distributions (matched ORs cannot be calculated directly from these numbers).

  • Adjusted for age at menarche, age at first live birth, menopausal status, Quetelet's index, family history of breast cancer in a first-degree relative, and epithelial hyperplasia.

  • Reference category.

  • § Domains II to V include the following amino acids: 117-142, 171-181, 234-258, and 270-286, respectively (41).

  • Not estimated.