Table 3.

Association between p53 intronic changes in benign breast tissue and risk of breast cancer

Type of intronic changeLevelNo. cases*No. controlsUnadjusted OR (95% CI)Adjusted OR (95% CI)
Any intronic changeWild-type4619011
Other changes17651.17 (0.59-2.32)0.99 (0.48-2.06)
Present19721.40 (0.72-2.74)1.49 (0.74-3.01)
Nonpolymorphic intronic changesWild-type4619011
Other changes251191.02 (0.55-1.89)0.90 (0.47-1.75)
Present11182.53 (1.05-6.09)2.84 (1.09-7.41)
  • * Unmatched distributions (matched ORs cannot be calculated directly from these numbers).

  • Adjusted for age at menarche, age at first live birth, menopausal status, Quetelet's index, family history of breast cancer in a first-degree relative, and epithelial hyperplasia.

  • Reference category.