Table 2.

Association between p53 exonic changes in DNA extracted from benign breast tissue and risk of breast cancer

Type of exonic changeLevelNo. cases*No. controlsUnadjusted OR (95% CI)Adjusted OR (95% CI)
Any exonic changeWild-type4619011
Other changes10451.27 (0.56-2.89)1.45 (0.61-3.42)
Present26921.29 (0.70-2.35)1.13 (0.60-2.16)
Nonpolymorphic exonic changesWild-type4619011
Other changes14751.00 (0.49-2.03)1.02 (0.48-2.13)
Present22621.59 (0.83-3.08)1.44 (0.71-2.92)
Exonic changes yielding amino acid changesWild-type4619011
Other changes15551.34 (0.65-2.77)1.41 (0.66-3.04)
Present21821.25 (0.66-2.36)1.11 (0.56-2.18)
Exonic changes yielding amino acid changes—unreadable changes excludedWild-type4619011
Other changes17591.40 (0.70-2.82)1.52 (0.73-3.16)
Present19781.20 (0.63-2.29)1.03 (0.52-2.06)
Silent mutationsWild-type4619011
Other changes291141.25 (0.70-2.26)1.22 (0.65-2.27)
Present7231.42 (0.54-3.72)1.22 (0.43-3.46)
Missense mutationsWild-type4619011
Other changes22761.43 (0.75-2.70)1.54 (0.79-3.00)
Present14611.11 (0.54-2.27)0.88 (0.41-1.92)
Mutations in untranslated regions (exons 2 and 11)Wild-type4619011
Other changes331331.22 (0.70-2.14)1.12 (0.62-2.02)
Present343.28 (0.63-17.10)5.69 (0.96-33.66)
Nonsense mutationsWild-type4619011
Other changes361351.29 (0.74-2.26)1.23 (0.68-2.21)
Present02§§
TransitionsWild-type4619011
Other changes14621.00 (0.48-2.08)0.95 (0.44-2.06)
Present22751.53 (0.81-2.89)1.46 (0.74-2.90)
TransversionsWild-type4619011
Other changes31981.55 (0.86-2.79)1.58 (0.84-2.95)
Present5390.65 (0.24-1.80)0.53 (0.18-1.55)
  • * Unmatched distributions (matched ORs cannot be calculated directly from these numbers).

  • Adjusted for age at menarche, age at first live birth, menopausal status, Quetelet's index, family history of breast cancer in a first-degree relative, and epithelial hyperplasia.

  • Reference category.

  • § Not estimated.