Table 4.

Two-locus XRCC4 tSNP haplotype tests of association with breast cancer risk and age at diagnosis (cases only)

Breast cancer risk
Age at diagnosis
OR (95% CI)PMean statisticP
X1-X2: G-G (frequency, 0.298)
    DOM*0.81 (0.63-1.03)0.084−0.770.444
    REC0.61 (0.39-0.94)0.0330.400.705
    HOM vs. other§0.57 (0.36-0.90)0.0140.230.842
    HET vs. other0.86 (0.67-1.12)0.295−0.980.333
    ANOVA0.590.565
X1-X2: G-A (frequency, 0.235)
    DOM1.30 (1.02-1.67)0.033−2.560.011
    REC1.08 (0.63-1.85)0.7670.430.667
    HOM vs. other1.20 (0.70-2.05)0.524−0.220.818
    HET vs. other1.32 (1.03-1.70)0.026−2.840.005
    ANOVA3.930.022
X1-X2: A-G (frequency, 0.468)
    DOM1.05 (0.78-1.41)0.7810.590.547
    REC1.06 (0.7831-1.4445)0.6852.810.007
    HOM vs. other1.08 (0.76-1.55)0.6822.200.028
    HET vs. other1.03 (0.75-1.41)0.871−0.380.704
    ANOVA3.950.025
  • NOTE: Interesting results are shown in bold.

  • * Carriage of the haplotype of interest.

  • Homozygous for haplotype of interest compared with all other diplotype combinations.

  • Homozygous for haplotype.

  • § Other diplotype combinations.

  • Heterzygous for haplotype of interest.

  • ANOVA comparison includes diploid combinations for the haplotype of interest (homozygous, heterozygous, and other).