Table 1.

Characteristics of breast cancer cohorts

Trio-sibs cohort*
Case-control cohort
Complete cohort
Trio casesTrio controlsSib casesSib controlsCasesControlsCasesControls
No. with complete genotype data5248183258233236464576
No. females (%)51 (98.1)15 (31.3)183 (100)258 (100)233 (100)236 (100)463 (99.8)538 (93.4)
Mean age at diagnosis ± SD50.5 ± 12.3NA53.7 ± 12.7NA58.2 ± 12.9NA55.6 ± 13.0NA
Mean age ± SD of controls at studyNA83.7 ± 9.8NA69.1 ± 15.1NA74.7 ± 14.7NA72.6 ± 15.2
Mean birth year ± SD1936.9 ± 15.01919.4 ± 8.41930.0 ± 12.81932.6 ± 13.21927.2 ± 13.91927.0 ± 13.71929.4 ± 13.91929.0 ± 13.7
  • * Trios cohort originally composed of 39 trios (two parents per affected daughter), 34 trios with complete genotype information. Some parents were also cases. Sibs cohort originally composed of 167 unique sibships with at least one affected and one unaffected sibling, 160 with complete genotype information. Five mothers (four affected and one unaffected) from trios cohort are also included as sisters in sibs cohort.

  • Case-control cohort originally composed of 236 cases (233 with complete genotype information) matched to 236 controls.

  • Complete cohort composed of all unique individuals from trios, sibs, and case-control cohorts plus 35 extra controls that did not qualify to be counted in the trio-sibs cohort.