Table 2.

Association of VEGF polymorphisms and breast cancer risk by age at diagnosis and menopausal status (the Shanghai Breast Cancer Study, 1996-1998)

GenotypeAll subjects
Menopausal status
Cases/controlsOR (95%CI)*Premenopausal
Postmenopausal
Cases/ControlsOR (95% CI)*Cases/ControlsOR (95% CI)*
T−460C
    TT616/6651.00 (reference)410/4101.00 (reference)203/2541.00 (reference)
    TC418/4790.94 (0.79-1.12)288/3160.92 (0.75-1.14)128/1601.01 (0.75-1.37)
    CC89/781.23 (0.89-1.70)54/531.06 (0.70-1.59)35/251.69 (0.98-2.93)
    Ptrend0.7750.6290.201
Pinteraction = 0.410
C+405G
    CC192/1821.00 (reference)118/1091.00 (reference)72/721.00 (reference)
    CG508/5980.81 (0.64-1.02)350/3750.90 (0.66-1.21)156/2220.74 (0.50-1.09)
    GG395/4180.90 (0.70-1.14)266/2870.90 (0.65-1.21)128/1291.00 (0.66-1.51)
    Ptrend0.6700.4390.602
Pinteraction = 0.173
C936T
    CC744/7931.00 (reference)507/5011.00 (reference)234/2901.00 (reference)
    CT334/3511.01 (0.85-1.21)215/2250.93 (0.74-1.17)117/1241.17 (0.86-1.59)
    TT31/510.65 (0.41-1.02)18/410.45 (0.25-0.79)13/101.60 (0.69-3.73)
    Ptrend0.3920.0410.179
Pinteraction = 0.041
  • Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval.

  • * The odds ratios, 95% confidence interval, and Ps for trend test were derived from logistic models, adjusting for age.

  • Pinteraction of T−460C, C+405G, and C936T with menopausal status.