Table 1.

Comparison of cases and controls by selected demographic characteristics, major risk factors for breast cancer in the Shanghai Breast Cancer Study

Subject characteristics*Case (n = 1,133)Control (n = 1,233)P
Demographic factors
    Age (y)47.6 ± 8.047.2 ± 8.70.213
    Education ≥ high school (%)43.542.90.765
Major risk factors
    Breast cancer in first-degree relatives (%)3.42.40.113
    Ever had breast fibroadenoma (%)9.75.1<0.001
    Age at menarche (y)14.5 ± 1.614.7 ± 1.70.002
    Age at the first birth (y)26.8 ± 4.126.2 ± 3.8<0.001
    Age at menopause (y)48.2 ± 4.647.5 ± 5.00.042
    Postmenopause (%)32.936.10.108
    Hormone replacement therapy (%)2.62.60.962
    No regularly physical activity (%)80.774.1<0.001
    Body mass index (kg/m2)23.5 ± 3.423.2 ± 3.40.028
    Waist-to-hip ratio0.81 ± 0.060.80 ± 0.060.004
VEGF polymorphisms§
    T−460C (rs833061, promoter)
        T1,650 (73.5)1,809 (74.0)0.67
        C596 (26.5)635 (26.0)
    C+405G (rs2010963, 5′UTR)
        C892 (40.7)962 (40.2)0.69
        G1,298 (59.3)1,434 (59.8)
    C936T (rs3025039, 3′UTR)
        C1,822 (82.1)1,937 (81.0)0.34
        T396 (17.9)453 (19.0)
  • Abbreviation: UTR, untranslated region.

  • * Values are presented as means ± SD among cases and controls unless otherwise noted.

  • Among parous women.

  • Among postmenopausal women.

  • § Values are presented as number of chromosomes and (%) among cases and controls.