Table 5.

Age- and race-adjusted ORs and 95% CIs for the association between the concurrent number of HPV types detected at a given visit and cervical lesions observed at specified follow-up returns

Lesion outcomeAssociation measuredNo. HPV typesOR (95% CI)*
All HPVsAll excluding HPV-16LR only
Any-grade SILAt the same visit01 (reference)1 (reference)1 (reference)
1 type25.7 (17.9-36.8)25.1 (16.7-37.7)13.0 (6.0-28.3)
2-3 types53.4 (34.5-82.7)51.8 (29.8-90.2)79.3 (9.1-687.7)
4-6 types84.1 (27.3-258.9)41.0 (3.8-445.6)x
Ptrend§<0.0010.004ND
6 mo later01 (reference)1 (reference)1 (reference)
1 type15.4 (8.7-27.1)11.7 (6.0-22.8)2.7 (0.3-29.9)
2-3 types25.9 (12.0-56.3)18.0 (5.3-61.1)
4-6 types247.3 (47.9-1276.4)
Ptrend0.009NDND
12 mo later01 (reference)1 (reference)1 (reference)
1 type7.6 (4.9-11.9)7.5 (4.3-13.0)9.9 (2.5-39.0)
2-3 types13.2 (6.9-25.4)9.6 (3.1-29.3)
4-6 types60.3 (12.0-302.7)
Ptrend0.033NDND
24 mo later01 (reference)1 (reference)
1 type4.2 (2.6-7.0)3.8 (2.0-7.4)
2-3 types6.2 (2.7-14.1)1.8 (0.2-15.9)
4-6 types
PtrendNDNDND
HSIL onlyAt the same visit01 (reference)1 (reference)
1 type19.8 (10.5-37.2)16.6 (7.7-35.8)
2-3 types20.6 (8.2-51.7)5.3 (0.5-52.4)
4-6 types122.0 (23.8-625.5)
Ptrend0.507NDND
6 mo later01 (reference)1 (reference)
1 type35.8 (7.8-164.7)43.9 (4.8-399.6)
2-3 types82.5 (14.6-467.8)
4-6 types1330.8 (98.9-17911.6)
Ptrend0.011NDND
12 mo later01 (reference)1 (reference)
1 type8.5 (3.4-20.9)6.1 (1.8-20.6)
2-3 types6.5 (1.2-36.2)10.5 (1.1-98.5)
4-6 types185.2 (26.31304.5)
Ptrend0.011NDND
24 mo later01 (reference)1 (reference)
1 type5.7 (1.9-17.4)
2-3 types11.8 (2.7-50.7)3.3 (0.5-21.1)
4-6 types
PtrendNDNDND
  • NOTE: Analysis by generalized estimating equations.

    Abbreviation: ND, not determined.

  • * Not estimated for combinations with no subjects in the stated exposure category or with no observed lesions.

  • All women positive at least once for HPV-16 during the entire follow-up were removed from the analysis.

  • All women positive at least once for any HR-HPVs during the entire follow-up were removed.

  • § Ps for linear trend in the relation between number of types and risk among HPV-positive women only.