Table 3.

Genotype distributions and genotypic risks for association with colorectal adenoma for cytokine and other inflammation-related genes

GenotypeCases, n (%)Controls, n (%)OR* (95% CI)
IL1B −31
    T/T74 (37.6)92 (48.2)1.0
    C/T99 (50.2)68 (35.6)1.8 (1.2-2.9)
    C/C24 (12.2)31 (16.2)0.9 (0.5-1.7)
    Ptrend = 0.01
C-carrier123 (62.4)99 (49.8)1.5 (1.0-2.3)
IL1B Ex5 +14
    C/C131 (59.0)129 (61.7)1.0
    C/T78 (35.1)66 (31.6)1.1 (0.7-1.7)
    T/T13 (5.9)14 (6.7)0.9 (0.4-2.0)
    Ptrend = 0.82
    T-carrier91 (41.0)80 (38.3)1.1 (0.7-1.6)
IL4 −584
    T/T132 (68)114 (64.8)1.0
    C/T53 (27.3)53 (30.1)0.9 (0.5-1.4)
    C/C9 (4.6)9 (5.1)0.8 (0.3-2.6)
    Ptrend = 0.86
    C-carrier60 (31.9)62 (35.2)0.8 (0.5-1.4)
IL4 −1098
    T/T177 (84.3)156 (82.1)1.0
    G/T33 (15.7)32 (16.8)0.9 (0.5-1.5)
    G/G0 (0)2 (1.1)
    Ptrend = 0.91
    G-carrier33 (15.7)34 (17.9)0.9 (0.5-1.5)
IL5 −74
    C/C94 (44.8)82 (43.2)1.0
    C/T92 (43.8)85 (44.7)0.9 (0.6-1.5)
    T/T24 (11.4)23 (12.1)0.8 (0.4-1.8)
    Ptrend = 0.90
    T-carrier116 (55.2)108 (56.8)0.9 (0.6-1.4)
IL6 −174
    G/G79 (38.7)83 (43.7)1.0
    C/G90 (44.1)81 (42.6)1.1 (0.7-1.8)
    C/C35 (17.2)26 (13.7)1.5 (0.8-2.9)
    Ptrend = 0.40
    C-carrier125 (61.3)107 (56.3)1.2 (0.8-1.9)
IL8 −251
    T/T52 (25.4)65 (34.0)1.0
    A/T87 (42.4)94 (49.2)1.2 (0.7-1.9)
    A/A66 (32.2)32 (16.8)2.7 (1.5-4.9)
    Ptrend = 0.002
    A-carrier153 (74.6)126 (66.0)1.5 (1.0-2.4)
IL10 −819
    C/C125 (56.3)117 (56.0)1.0
    C/T76 (34.2)79 (37.8)1.0 (0.6-1.5)
    T/T21 (9.5)13 (6.2)2.1 (0.9-4.8)
    Ptrend = 0.19
    T-carrier97 (43.7)92 (44.0)1.1 (0.7-1.6)
IL10 −1082
    A/A61 (27.5)55 (26.6)1.0
    A/G114 (51.4)123 (59.4)0.8 (0.5-1.3)
    G/G47 (21.1)29 (14.0)1.3 (0.7-2.4)
    Ptrend = 0.17
    G-carrier161 (72.5)152 (73.4)0.9 (0.6-1.4)
IL13 −1069
    C/C120 (61.5)102 (59.7)1.0
    C/T67 (34.4)58 (33.9)1.0 (0.6-1.6)
    T/T8 (4.1)11 (6.4)0.7 (0.2-1.8)
    Ptrend = 0.69
    T-carrier75 (38.5)69 (40.3)1.0 (0.6-1.5)
IL13 IVS3 −24
    C/C128 (61.5)110 (57.0)1.0
    C/T70 (33.7)73 (37.8)0.8 (0.5-1.2)
    T/T10 (4.8)10 (5.2)0.8 (0.3-2.3)
    Ptrend = 0.55
    T-carrier80 (37.5)83 (43.0)0.8 (0.5-1.2)
LTA IVS1 −82
    G/G85 (38.8)76 (37.1)1.0
    C/G107 (48.9)102 (49.8)1.0 (0.6-1.5)
    C/C27 (12.3)27 (13.1)0.9 (0.5-1.6)
    Ptrend = 0.91
    C-carrier134 (61.2)129 (62.9)1.0 (0.6-1.4)
LTA IVS1+90
    A/A90 (39.8)88 (42.1)1.0
    A/G101 (44.7)92 (44.0)1.2 (0.8-1.8)
    G/G35 (15.5)29 (13.9)1.2 (0.7-2.2)
    Ptrend = 0.71
    G-carrier136 (60.2)114 (57.9)1.2 (0.8-1.7)
TNF −308
    G/G146 (67.3)139 (68.8)1.0
    A/G59 (27.2)57 (28.2)1.0 (0.7-1.6)
    A/A12 (5.5)6 (3.0)1.9 (0.7-5.4)
    Ptrend = 0.46
    A-carrier71 (32.7)63 (31.2)1.1 (0.7-1.7)
PPARG −Pro12Ala
    G/G153 (77.3)146 (79.4)1.0
    G/C41 (20.7)37 (20.1)1.1 (0.7-1.8)
    C/C4 (2.0)1 (0.5)3.2 (0.3-31.1)
    Ptrend = 0.56
    C-carrier45 (22.7)38 (21.5)1.2 (0.7-1.9)
PTGS2 −765
    G/G151 (71.9)141 (71.9)1.0
    G/C54 (25.7)52 (26.5)0.9 (0.6-1.4)
    C/C5 (2.4)3 (1.5)1.3 (0.3-5.9)
    Ptrend = 0.85
    C-carrier59 (28.1)55 (28.0)0.9 (0.6-1.5)
PTGS2 Ex3 −8
    G/G154 (73.3)142 (72.1)1.0
    G/C52 (24.8)51 (25.9)1.0 (0.6-1.6)
    C/C4 (1.9)4 (2.0)1.2 (0.3-5.1)
    Ptrend = 0.97
    C-carrier56 (26.7)55 (27.9)1.0 (0.6-1.6)
PTGS2 IVS5 −275
    T/T149 (71.0)136 (69.0)1.0
    T/G54 (25.7)57 (28.9)0.8 (0.5-1.3)
    G/G7 (3.3)4 (2.1)1.4 (0.4-5.1)
    Ptrend = 0.53
    G-carrier61 (29.0)61 (31.0)0.9 (0.6-1.3)
PTGS2 Ex10 +837
    C/C92 (43.8)77 (39.1)1.0
    T/C88 (41.9)102 (51.8)0.7 (0.5-1.1)
    T/T30 (14.3)18 (9.1)1.2 (0.6-2.4)
    Ptrend = 0.16
    T-carrier118 (56.2)120 (60.9)0.8 (0.5-1.2)
  • * ORs adjusted for age, sex, and ethnicity.