Table 4.

ORs (95% CIs) of distal colon adenoma by quintiles of meat intake before and after adjusting for MDM and MeIQx, HPFS

Categories of meat intake
Ptrend
1 (Low)2345
Total red meat (servings/wk), median1.12.33.44.87.2
    Cases/controls96/3,00697/2,285128/2,779124/2,702136/2,679
    Multivariable*1.001.16 (0.86-1.55)1.24 (0.93-1.64)1.19 (0.88-1.59)1.18 (0.87-1.62)0.43
    Multivariable (+MDM)1.001.12 (0.84-1.51)1.19 (0.89-1.58)1.12 (0.83-1.51)1.10 (0.80-1.52)0.75
    Multivariable (+MeIQx)1.001.12 (0.83-1.51)1.17 (0.88-1.58)1.11 (0.81-1.52)1.10 (0.79-1.54)0.79
Hamburger (servings/wk), median0.160.650.821.52.5
    Cases/controls82/2,457113/3,099120/2,640134/2,782132/2,473
    Multivariable*1.000.97 (0.72-1.30)1.19 (0.88-1.60)1.22 (0.91-1.64)1.24 (0.91-1.70)0.10
    Multivariable (+MDM)1.000.94 (0.70-1.27)1.14 (0.85-1.54)1.16 (0.86-1.57)1.17 (0.85-1.61)0.22
    Multivariable (+MeIQx)1.000.94 (0.69-1.26)1.13 (0.83-1.54)1.16 (0.85-1.59)1.17 (0.84-1.64)0.22
Beef, lamb, and pork as main dish (servings/wk), median0.330.821.32.13.3
    Cases/controls80/2,551130/2,911129/2,901112/2,590130/2,498
    Multivariable*1.001.28 (0.96-1.71)1.20 (0.89-1.61)1.12 (0.82-1.53)1.26 (0.92-1.74)0.49
    Multivariable (+MDM)1.001.23 (0.92-1.65)1.14 (0.85-1.54)1.06 (0.77-1.45)1.17 (0.85-1.62)0.81
    Multivariable (+MeIQx)1.001.23 (0.91-1.65)1.14 (0.84-1.55)1.05 (0.76-1.46)1.18 (0.84-1/65)0.81
Processed meat (servings/wk), median0.160.651.32.44.5
    Cases/controls77/2,68188/2,275140/3,115126/2,716150/2,664
    Multivariable*1.001.22 (0.89-1.70)1.34 (1.00-1.80)1.36 (1.00-1.84)1.52 (1.12-2.08)0.02
    Multivariable (+MDM)1.001.20 (0.87-1.65)1.30 (0.97-1.74)1.31 (0.96-1.78)1.46 (1.06-1.99)0.04
    Multivariable (+MeIQx)1.001.20 (0.87-1.64)1.30 (0.96-1.76)1.31 (0.96-1.80)1.47 (1.06-2.04)0.05
Chicken + turkey (servings/wk), median0.981.82.53.24.5
    Cases/controls137/2,895104/2,423132/2,737104/2,757104/2,639
    Multivariable*1.000.94 (0.72-1.23)1.12 (0.87-1.44)0.88 (0.67-1.15)0.90 (0.69-1.19)0.38
    Multivariable (+MDM)1.000.93 (0.71-1.21)1.09 (0.85-1.41)0.85 (0.65-1.11)0.87 (0.66-1.15)0.26
    Multivariable (+MeIQx)1.000.94 (0.72-1.23)1.13 (0.88-1.45)0.89 (0.68-1.16)0.92 (0.70-1.21)0.46
  • * Models adjusted for age (in 5-year categories), family history of colorectal cancer (first-degree relative), reason for endoscopy (screening versus others), negative endoscopy before 1996 (yes versus no), physical activity (metabolic equivalent-hours/wk in quintiles), smoking status (never smokers, past smokers who quit ≤10 years ago, past smokers who quit >10 years ago, current smokers), race, aspirin use (<2/wk versus ≥2/wk), total energy intake (in quintiles), and calcium and folate intake (in quintiles).