Table 3.

ORs (95% CIs) of distal colon adenoma by quintiles of heterocyclic amine and MDM intake before and after adjusting for red and processed meat intake, HPFS

Heterocyclic amine intake (ng/d)/mutagenicity (revertant colonies/d)
Ptrend
1 (Low)2345
Total MeIQx intake (ng/d), median1.55.39.917.335.0
    Cases/controls88/2,720113/2,693119/2,688124/2,681137/2,669
    Multivariable*1.001.18 (0.88-1.57)1.22 (0.91-1.63)1.19 (0.89-1.59)1.28 (0.95-1.71)0.22
    Multivariable (+red meat)1.001.15 (0.86-1.54)1.17 (0.87-1.58)1.15 (0.84-1.56)1.23 (0.90-1.68)0.34
    Multivariable (+processed meat)1.001.12 (0.84-1.50)1.13 (0.84-1.52)1.08 (0.80-1.46)1.14 (0.83-1.55)0.66
Total PhIP intake (ng/d), median14.439.170.6117.4220.4
    Cases/controls108/2,696110/2,700108/2,699122/2,683133/2,673
    Multivariable*1.000.97 (0.74-1.28)0.93 (0.71-1.23)1.05 (0.80-1.38)1.11 (0.85-1.46)0.25
    Multivariable (+red meat)1.000.95 (0.72-1.26)0.91 (0.69-1.20)1.03 (0.78-1.35)1.09 (0.83-1.44)0.29
    Multivariable (+processed meat)1.000.95 (0.72-1.25)0.89 (0.68-1.18)1.01 (0.77-1.33)1.08 (0.82-1.42)0.32
Total DiMeIQx intake (ng/d), median00.20.51.24.0
    Cases/controls183/4,37239/1,26695/2,222129/2,873135/2,718
    Multivariable*1.000.72 (0.51-1.03)0.97 (0.75-1.25)0.99 (0.79-1.26)1.08 (0.86-1.37)0.22
    Multivariable (+red meat)1.000.71 (0.50-1.02)0.96 (0.74-1.24)0.97 (0.77-1.23)1.07 (0.85-1.36)0.25
    Multivariable (+processed meat)1.000.70 (0.49-1.00)0.94 (0.73-1.22)0.96 (0.75-1.21)1.06 (0.84-1.35)0.25
MDM (revertant colonies/d), median7111,7362,8314,3478,125
    Cases/controls90/2,718100/2,705127/2,676135/2,672129/2,680
    Multivariable*1.001.05 (0.78-1.41)1.32 (1.00-1.75)1.39 (1.05-1.84)1.29 (0.97-1.72)0.08
    Multivariable (+red meat)1.001.03 (0.77-1.39)1.30 (0.98-1.73)1.36 (1.03-1.81)1.26 (0.94-1.69)0.10
    Multivariable (+processed meat)1.001.02 (0.76-1.37)1.27 (0.96-1.69)1.33 (1.00-1.77)1.23 (0.92-1.65)0.13
  • * Models adjusted for age (in 5-year categories), family history of colorectal cancer (first-degree relative), reason for endoscopy (screening versus others), negative endoscopy before 1996 (yes versus no), physical activity (metabolic equivalent-hours/wk in quintiles), smoking status (never smokers, past smokers who quit ≤10 years ago, past smokers who quit >10 years ago, current smokers), race, aspirin use (<2/wk versus ≥2/wk), total energy intake (in quintiles), and calcium and folate intake (in quintiles).