Table 1.

Comparison of biological activities, epidemiologic risk classification, and phylogenetic classification of the whole genomes of the HPV types used in this study

HPVp53ImmortalizationRisk classification
Phylogeny of
12
18++HCA7
39+NDHC
45++HC
70+NDL
16++HCA9
33++HC
35+NDHC
52+NDHC
58++HC
53++PHA6
56++HC
66++PHC
51+NDHCA5
82++H
6aLPCA10
11LPC
44NDL
61LA3
54NDLA13
  • NOTE: The ability of E6 proteins to induce p53 degradation (p53) or of HPV genomes to immortalize normal human keratinocytes (immortalization) is indicated by the following: +, able; −, unable; or ND, has not been determined. Data for virus genomes not analyzed in this study are derived from other studies (8, 9, 11-14). For the epidemiologic risk classification, publications by Munoz et al. (4) or the IARC study group (7) were used. Risk classification: −, undetermined. The last row shows the phylogenetic classification of HPV genomes (6, 38).

    Abbreviations: H, high risk; PH, possible high risk; L, low risk; C, carcinogenic; PC, possibly carcinogenic.