Table 5.

Cell cycle markers related to different viral and clinical outcomes

MarkerViral outcome
Significance*
Persistent HPV, OR (95% CI)HPV cleared, OR (95% CI)
MI1.92 (1.19-2.65)1.86 (1.13-2.60)0.909
AI1.56 (1.15-1.97)1.43 (0.96-1.90)0.670
Ki-67§13.55 (8.48-18.62)14.51 (10.80-18.21)0.756
p21§12.29 (7.18-17.39)11.38 (6.59-16.18)0.793
Cyclin A§19.48 (13.14-25.81)19.50 (13.81-25.18)0.996
E2F4§1.77 (0.15-3.70)0.48 (0.10-0.85)0.173
p105§35.71(22.01-49.41)49.02 (38.04-60.01)0.131
p107§11.55 (6.92-16.18)13.23 (7.48-18.98)0.661
p130§47.66 (32.39-62.94)33.88 (21.04-46.73)0.161
Clinical outcome
Persistent abnormal Pap smear, OR (95% CI)
Abnormal Pap smear cleared, OR (95% CI)
MI2.50 (1.63-3.36)2.00 (1.20-2.79)0.392
AI1.44 (0.92-1.95)1.60 (1.10-2.11)0.648
Ki-67§14.68 (10.18-19.18)16.53 (11.62-21.44)0.573
p21§12.85 (7.55-18.15)10.88 (6.03-15.74)0.583
Cyclin A§17.29 (11.01-23.57)20.20 (13.83-26.56)0.509
E2F4§2.01 (0.67-4.70)0.67 (0.05-1.41)0.266
p105§40.86 (28.85-52.88)40.00 (25.05-54.94)0.926
p107§9.92 (5.84-14.00)9.85 (5.25-14.46)0.981
p130§27.85 (11.83-43.87)42.00 (28.25-55.74)0.173
  • * Mann-Whitney U test.

  • No. mitotic figures/mm2.

  • No. apoptotic cells/mm2.

  • § Percentages of stained cells in 10 randomly selected fields (×40).