Table 4.

Multivariable HRs and 95% CIs for NHL subtypes according to baseline dietary intake of one-carbon-related nutrients (tertiles), ATBC Study cohort, 1985-2001 (N = 27,111)

Diffuse lymphoma (n = 54)
Follicular lymphoma* (n = 16)
SLL (n = 24)
CLL (n = 41)
SLL/CLL (n = 65)
T-cell lymphoma* (n = 17)
nHR (95% CI)nHR (95% CI)nHR (95% CI)nHR (95% CI)nHR (95% CI)nHR (95% CI)
Folate (μg/d)
    T1 (128-302)161.0 (reference)71.0 (reference)81.0 (reference)111.0 (reference)191.0 (reference)51.0 (reference)
    T2 (303-348)171.12 (0.56-2.22)90.69 (0.25-1.90)91.08 (0.42-2.83)131.25 (0.56-2.80)221.18 (0.63-2.20)51.13 (0.33-3.93)
    T3 (349-703)211.46 (0.75-2.84)70.84 (0.30-2.38)171.73 (0.80-3.76)241.34 (0.73-2.48)71.74 (0.54-3.93)
    Ptrend0.260.480.740.160.350.35
Vitamin B12 (μg/d)
    T1 (1.68-8.72)231.0 (reference)71.0 (reference)91.0 (reference)131.0 (reference)221.0 (reference)91.0 (reference)
    T2 (8.73-11.80)180.75 (0.38-1.45)90.79 (0.25-2.52)60.49 (0.16-1.45)161.45 (0.66-3.17)220.98 (0.52-1.85)80.95 (0.32-2.77)
    T3 (11.81-62.02)130.53 (0.24-1.21)90.60 (0.19-1.92)121.21 (0.48-3.08)210.95 (0.46-1.95)
    Ptrend0.130.690.440.700.880.92
Vitamin B6 (mg/d)
    T1 (1.06-2.26)211.0 (reference)71.0 (reference)91.0 (reference)151.0 (reference)241.0 (reference)91.0 (reference)
    T2 (2.27-2.61)190.96 (0.51-1.80)90.72 (0.26-2.01)90.94 (0.37-2.40)120.85 (0.40-1.84)210.89 (0.49-1.61)80.57 (0.21-1.55)
    T3 (2.62-11.47)140.77 (0.37-1.57)60.60 (0.20-1.81)141.10 (0.51-2.40)200.89 (0.47-1.68)
    Ptrend0.470.530.380.820.720.27
Vitamin B2 (mg/d)
    T1 (0.86-2.59)201.0 (reference)71.0 (reference)41.0 (reference)171.0 (reference)211.0 (reference)91.0 (reference)
    T2 (2.60-3.08)150.86 (0.43-1.73)90.79 (0.27-2.31)102.55 (0.78-8.34)100.59 (0.26-1.30)200.95 (0.51-1.79)80.73 (0.25-2.12)
    T3 (3.09-7.37)191.27 (0.63-2.57)102.66 (0.76-9.24)140.85 (0.39-1.88)241.19 (0.63-2.28)
    Ptrend0.550.660.140.630.600.57
Methionine (g/d)
    T1 (0.55-1.85)171.0 (reference)61.0 (reference)71.0 (reference)161.0 (reference)231.0 (reference)121.0 (reference)
    T2 (1.86-2.12)201.41 (0.72-2.78)101.07 (0.35-3.29)91.24 (0.45-3.43)100.67 (0.30-1.53)190.85 (0.46-1.60)50.28 (0.09-0.88)
    T3 (2.13-5.10)171.42 (0.66-3.05)81.09 (0.35-3.36)151.10 (0.49-2.48)231.09 (0.56-2.10)
    Ptrend0.370.910.890.840.810.03
Alcohol (g/d)
    None30.45 (0.14-1.49)20.71 (0.16-3.26)20.64 (0.14-2.86)61.41 (0.55-3.65)81.08 (0.49-2.38)10.41 (0.05-3.22)
    Low (0.04-13.3)271.0 (reference)101.0 (reference)121.0 (reference)151.0 (reference)271.0 (reference)91.0 (reference)
    High (13.4-278.5)240.95 (0.54-1.68)40.55 (0.17-1.79)101.04 (0.44-2.47)201.84 (0.93-3.64)301.48 (0.87-2.52)70.93 (0.34-2.55)
  • NOTE: Multivariable models were adjusted for age and calories and additionally for vitamin B12 (in the models of folate, vitamin B6, vitamin B2, and methionine), for methionine, vitamin D, and ω-3 fatty acids from fish (in the vitamin B12 model), and for serum high-density lipoprotein cholesterol (in the alcohol model).

    Abbreviations: SLL, small lymphocytic lymphoma; CLL, chronic lymphocytic leukemia.

  • * Cells with case counts <5 were combined with adjacent categories for follicular and T-cell lymphoma subtypes, except for alcohol.