Table 4.

Cell cycle markers in high-risk HPV-positive and high-risk HPV-negative lesions

MarkerHCII positive, OR (95% CI)HCII negative, OR (95% CI)Significance*
MI2.87 (2.10-3.64)2.81 (0.05-5.68)0.959
AI1.82 (1.43-2.22)1.62 (0.13-3.11)0.743
Ki-67§14.04 (11.27-16.80)10.40 (3.80-16.99)0.303
p21§12.40 (8.88-15.91)9.80 (4.40-15.19)0.525
Cyclin A§19.88 (16.18-23.59)6.78 (3.80-9.77)0.002
E2F4§0.49 (0.26-0.72)0.68 (0.40-1.76)0.609
p105§42.98 (35.50-50.46)35.00 (21.51-48.48)0.351
p107§12.72 (9.40-16.05)11.31 (6.34-16.28)0.705
p130§40.12 (31.08-49.17)22.35 (3.50-41.20)0.085
  • * Mann-Whitney U test.

  • No. mitotic figures/mm2.

  • No. apoptotic cells/mm2.

  • § Percentages of stained cells in 10 randomly selected fields (×40).