Table 3.

Adjusted HRs and 95% CIs for NHL (n = 195) according to baseline dietary intake of one-carbon-related nutrients (quartiles) and supplement use, ATBC Study cohort, 1985-2001 (N = 27,111)

CasesPerson-yearsAge- and energy-adjusted HR (95% CI)Multivariable HR (95% CI)
Folate (μg/d)
    Q1 (128-290)5078,3131.00 (—)1.00 (—)
    Q2 (291-325)4281,1470.83 (0.55-1.25)0.88 (0.58-1.32)
    Q3 (326-362)5881,5101.15 (0.79-1.68)1.26 (0.86-1.85)
    Q4 (363-703)4482,2600.91 (0.61-1.36)1.03 (0.68-1.55)
    Ptrend0.980.54
Folate supplement
    No186304,5331.00 (—)1.00 (—)
    Yes918,6990.77 (0.39-1.50)0.76 (0.39-1.48)
Vitamin B12 (μg/d)
    Q1 (1.68-8.05)6281,3001.00 (—)1.00 (—)
    Q2 (8.06-10.11)5080,1820.81 (0.56-1.18)0.81 (0.55-1.20)
    Q3 (10.12-12.87)4880,6070.80 (0.55-1.16)0.81 (0.53-1.24)
    Q4 (12.88-62.02)3581,1430.58 (0.38-0.88)0.61 (0.37-1.00)
    Ptrend0.010.06
Vitamin B12 supplement
    No184300,0541.00 (—)1.00 (—)
    Yes1123,1770.76 (0.41-1.39)0.74 (0.40-1.36)
Vitamin B6 (mg/d)
    Q1 (1.06-2.16)6178,5741.00 (—)1.00 (—)
    Q2 (2.17-2.43)5180,4630.83 (0.57-1.21)0.88 (0.61-1.29)
    Q3 (2.44-2.72)3881,7430.63 (0.42-0.94)0.70 (0.46-1.06)
    Q4 (2.73-11.47)4582,4520.76 (0.52-1.12)0.91 (0.60-1.37)
    Ptrend0.080.42
Vitamin B6 supplement
    No173282,2871.00 (—)1.00 (—)
    Yes2240,9440.87 (0.56-1.36)0.85 (0.55-1.34)
Vitamin B2 (mg/d)
    Q1 (0.86-2.44)4982,5131.00 (—)1.00 (—)
    Q2 (2.45-2.83)4581,4390.91 (0.61-1.36)1.05 (0.69-1.59)
    Q3 (2.84-3.23)5880,1671.18 (0.81-1.73)1.50 (1.00-2.25)
    Q4 (3.24-7.37)4379,1120.88 (0.59-1.33)1.25 (0.79-1.98)
    Ptrend0.860.17
Vitamin B2 supplement
    No175287,6181.00 (—)1.00 (—)
    Yes2035,6140.92 (0.58-1.46)0.90 (0.56-1.44)
Methionine (g/d)
    Q1 (0.55-1.78)6380,7651.00 (—)1.00 (—)
    Q2 (1.79-1.99)4280,9440.67 (0.45-0.99)0.76 (0.51-1.13)
    Q3 (2.00-2.20)3881,1140.61 (0.41-0.91)0.74 (0.48-1.14)
    Q4 (2.21-5.10)5280,4080.85 (0.59-1.23)1.15 (0.75-1.76)
    Ptrend0.300.66
Alcohol (g/d)
    None1934,6450.70 (0.42-1.19)0.67 (0.40-1.14)
    Q1 (0.04-5.2)5570,9511.00 (—)1.00 (—)
    Q2 (5.3-13.3)4373,5970.80 (0.54-1.19)0.83 (0.56-1.24)
    Q3 (13.4-27.6)4672,9130.90 (0.61-1.34)0.97 (0.65-1.45)
    Q4 (27.7-278.5)3271,1250.67 (0.43-1.05)0.76 (0.49-1.20)
  • NOTE: All nutrients, except alcohol and supplements, were energy adjusted using the residual method (23) to account for their significant correlations with energy.

    Multivariable models of one-carbon nutrients adjusted for age, calories, education (three categories: elementary school or less, up to junior high school, high school or more), smoking history (years smoked), and additionally for the following: folate model adjusted for vitamin B12; vitamin B12 model adjusted for methionine, vitamin D, and ω-3 fatty acids from fish; vitamin B6 model adjusted for vitamin B12; vitamin B2 model adjusted for vitamin B12; methionine model adjusted for vitamin B12; alcohol model adjusted for serum high-density lipoprotein cholesterol.