Table 1.

Summary of case control studies on NQO1 Pro187Ser polymorphisms and lung, bladder, and colorectal cancer risk

First authorYear of publicationCountryControl sourceEthnicityCasesFrequency of CT/TTControlsFrequency of CT/TTCrude OR* (95% CI)Adjusted OR* (95% CI)Adjustment factorsRef.
Lung cancer
    Lawson2005FinlandPopulation based (nested case-control)White3530.313600.330.93 (0.68-1.27)0.93 (0.67-1.28)Age, no. cigarettes smoked, years smoked, and intervention assignment(45)
    Sorensen2005DenmarkPopulation based (case-cohort)White2560.362690.341.13 (0.76-1.64)1.11 (0.75-1.63)Duration of smoking(40)
0.89 (0.36-2.20)§0.90 (0.37-2.16)§
    Skuladottir2005DenmarkMixedWhite2320.293460.340.79 (0.53-1.20)0.74 (0.47-1.14)Age, sex, and study(39)
    Alexandrie2004SwedenLaboratory workersWhite5240.345300.311.17 (0.90-1.52)1.11 (0.76-1.60)Age and sex(26)
1.30 (0.53-3.18)§1.41 (0.45-4.36)§
    Lewis2001United KingdomHospitalWhite940.321650.241.52 (0.83-2.77)1.31 (0.66-2.58)Age, sex, and pack-year smoked(32)
    Xu2001United StatesFriends/FamilyWhite (97%)8140.351,1230.351.00 (0.83-1.21)(16)
    Benhamou2001FranceHospitalWhite1500.431720.391.20 (0.77-1.87)1.20 (0.70-2.0)Age, sex, smoking, and occupation exposure(27)
    HungUnpublished**Eastern EuropeHospitalWhite2,2240.332,2790.331.04 (0.92-1.18)(44)
    Lan2004ChinaPopulation basedChinese1190.691090.710.92 (0.52-1.62)0.91 (0.51-1.62)Sex and pack-year smoked(31)
    Liang2004ChinaHospitalChinese1520.771520.651.66 (1.01-2.74)(33)
    Lin2003TaiwanHospitalChinese1980.713320.710.99 (0.67-1.46)0.93 (0.63-1.23)Age, sex, and smoking status(36)
    Yin2001ChinaHospitalChinese840.67840.690.90 (0.47-1.71)(43)
    Lin2000ChinaHospitalChinese950.871360.702.89 (1.43-5.87)(34)
    Sunaga††2002JapanHospitalJapanese1980.581520.660.76 (0.48-1.20)0.69 (0.67-0.72)Age, sex, and smoking status(41)
0.60 (0.30-1.18)§0.47 (0.22-0.97)§
    Hamajima2002JapanHospitalJapanese1920.556400.630.72 (0.52-1.00)0.71 (0.50-1.0)Age and sex(30)
    Saldivar2005United StatesPrivate physician groupWhite6830.346830.301.19 (0.95-1.50)1.19 (0.95-1.50)Age, sex, and smoking status(38)
African American1070.371070.361.08 (0.62-1.89)1.08 (0.62-1.90)
Hispanic360.58360.581.00 (0.39-2.55)0.99 (0.38-2.58)
    Bock‡‡2005United StatesPopulation basedWhite1300.281440.400.61 (0.37-1.01)0.62 (0.37-1.05)Age and sex(28)
African American310.32290.281.25 (0.41-3.79)0.78 (0.22-2.75)
    Chen1999United States, HawaiiPopulation basedJapanese1090.441670.620.73 (0.44-1.22)0.8 (0.4-1.5)Age, sex, ethnicity, smoking, saturated fat, and vegetable intake(29)
0.33 (0.13-0.82)§0.3 (0.1-0.7)§
White1350.401710.391.06 (0.67-1.68)0.8 (0.4-1.5)
Hawaiian830.271020.410.52 (0.28-0.96)0.6 (0.2-1.3)
    Wiencke1997United StatesCommunityAfrican American1160.341360.390.79 (0.47-1.33)(42)
Hispanic610.521610.680.53 (0.29-0.96)
Bladder cancer
    Broberg2005SwedenPopulation basedWhite610.301560.310.70 (0.35-1.43)0.72 (0.34-1.50)Age, sex, and smoking(46)
4.15 (0.95-18.12)§3.90 (0.85-18.0)§
    Terry2005United StatesHospitalMostly White (>90%)2350.342140.301.19 (0.80-1.77)1.10 (0.70-1.70)Age, sex, ethnicity, and smoking(53)
    Hung2004ItalyHospitalWhite2010.442140.371.33 (0.90-1.97)1.32 (0.87-2.00)Age, education, and pack-year smoked(48)
    Sanyal2004SwedenSame geographic areaWhite2990.311240.330.91 (0.58-1.43)(52)
    Park2003United StatesPrivate physician groupWhite2320.392390.321.36 (0.93-1.99)1.51 (1.01-2.25)Age, sex, and smoking status(50)
    Schulz1997GermanyUniversityWhite990.312600.251.37 (0.82-2.28)(54)
    Moore2004ArgentinaPopulation basedHispanic1060.421080.440.92 (0.54-1.58)(49)
    Choi2003KoreaHospitalKorean1770.541700.620.72 (0.47-1.10)0.63 (0.37-1.00)Age, urinary track stones, and smoking(47)
Colorectal cancer
    van der Logt2005NetherlandsPopulation basedWhite3710.394150.301.52 (1.13-2.04)1.60 (1.03-2.40)Age and sex(59)
    Mitrou2002United KingdomScreening trialWhite2060.363450.331.18 (0.82-1.69)0.97 (0.65-1.46)Age and sex(57)
    Sachse2002United KingdomPopulation basedWhite4900.425930.411.03 (0.81-1.31)(58)
    Lafuente2000SpainHospitalWhite2470.242960.201.27 (0.85-1.91)(56)
    Harth2000GermanyPopulationWhite3230.352050.341.05 (0.73-1.52)(55)
    Hamajima2002JapanHospitalJapanese1460.586400.630.84 (0.58-1.21)0.95 (0.58-1.57)§§Age and sex(30)
0.74 (0.45-1.22)∥∥
  • * ORs are (C/T+T/T) vs C/C unless otherwise specified.

  • Males with a smoking history only.

  • OR C/T vs C/C.

  • § OR T/T vs C/C.

  • Pooled study: all subjects under 60 years (non–small cell lung cancer).

  • Smokers only.

  • ** Study period: 1998-2002.

  • †† Adenocarcinoma only.

  • ‡‡ Never smokers only.

  • §§ OR (C/T+T/T) vs C/C for colon cancer.

  • ∥∥ OR (C/T+T/T) vs C/C for rectum cancer.