Table 5.

Relationship between anthropometric factors and risk of different histologic types of breast cancer

Controls (n = 4,681)Ductal (n = 3,457)
Lobular (n = 274)
Ductal-lobular (n = 261)
Medullary (n = 91)
Tubular (n = 77)
Comedo (n = 70)
Mucinous (n = 61)
nnOR (95% CI)nOR (95% CI)nOR (95% CI)nOR (95% CI)nOR (95% CI)nOR (95% CI)nOR (95% CI)
Height, quartiles (cm): all women
≤1601,4931,0271.0 (ref)771.0 (ref)651.0 (ref)291.0 (ref)241.0 (ref)211.0 (ref)111.0 (ref)
161-1691,9551,5031.1 (1.0-1.2)*1261.2 (0.9-1.6)1161.3 (1.0-1.8)330.9 (0.6-1.5)331.0 (0.6-1.7)311.1 (0.7-2.0)271.8 (0.9-3.7)
≥1701,2339271.1 (1.0-1.2)711.1 (0.8-1.6)801.5 (1.0-2.1)*291.3 (0.8-2.2)201.0 (0.5-1.8)181.0 (0.5-2.0)232.5 (1.2-5.1)*
Phomogeneity = 0.52

Controls (n = 1,825),
Ductal (n = 1,427)
Lobular (n = 92)
Ductal-lobular (n = 123)
Medullary (n = 47)
Tubular (n = 25)
Comedo (n = 35)
Mucinous (n = 20)
nn
OR (95% CI)
n
OR (95% CI)
n
OR (95% CI)
n
OR (95% CI)
n
OR (95% CI)
n
OR (95% CI)
n
OR (95% CI)
BMI at reference date, tertiles (kg/m2): premenopausal
≤21.596785311.0 (ref)321.0 (ref)381.0 (ref)151.0 (ref)171.0 (ref)121.0 (ref)91.0 (ref)
21.60-25.706765561.0 (0.9-1.2)371.1 (0.7-1.8)421.1 (0.7-1.8)130.7 (0.3-1.5)120.7 (0.3-1.4)131.1 (0.5-2.5)70.9 (0.3-2.4)
≥25.706935421.0 (0.8-1.2)230.6 (0.4-1.1)431.1 (0.7-1.7)221.0 (0.5-2.0)30.1 (0.0-0.5)*121.0 (0.4-2.4)70.9 (0.3-2.4)
Phomogeneity = 0.28

Controls (n = 1,804),
Ductal (n = 1,304)
Lobular (n = 151)
Ductal-lobular (n = 119)
Medullary (n = 25)
Tubular (n = 36)
Comedo (n = 19)
Mucinous (n = 28)
nn
OR (95% CI)
n
OR (95% CI)
n
OR (95% CI)
n
OR (95% CI)
n
OR (95% CI)
n
OR (95% CI)
n
OR (95% CI)
BMI at reference date, tertiles (kg/m2): postmenopausal
≤23.406714491.0 (ref)571.0 (ref)561.0 (ref)41.0 (ref)181.0 (ref)51.0 (ref)141.0 (ref)
23.41-27.816775171.2 (1.0-1.4)470.8 (0.5-1.2)340.7 (0.4-1.0)111.7 (0.5-5.7)100.6 (0.3-1.3)121.8 (0.6-5.4)90.7 (0.3-1.5)
≥27.826774511.0 (0.9-1.2)470.8 (0.5-1.3)290.6 (0.4-1.0)*111.3 (0.4-4.6)80.5 (0.2-1.1)50.7 (0.2-2.6)70.5 (0.2-1.4)
Phomogeneity = 0.008
  • NOTE: All ORs are adjusted for age, race, and study site.

  • * P < 0.05.

  • Phomogeneity in the ORs across the six different histologic types of breast cancer.