Table 3.

Odds ratios and 95% confidence intervals in relation to the combined effects of years since stopped smoking and smoking doses for hyperplastic polyps and adenomas of the distal colon and rectum (Prostate, Lung, Colorectal, and Ovarian Trial, 1993-2000)

Years since quit
Ptrend*
≥20
10 to <20
0 to <10
CasesOR (95% CI)CasesOR (95% CI)CasesOR (95% CI)
Hyperplastic polyps only
    Cigarettes smoked per day
        1-10881.2 (0.9-1.5)341.7 (1.2-2.5)722.6 (2.0-3.3)<0.0001
        11-201111.2 (1.0-1.5)651.9 (1.4-2.5)2084.0 (3.3-4.8)<0.0001
        ≥211041.5 (1.2-1.8)1172.6 (2.1-3.2)2334.5 (3.8-5.4)<0.0001
        Ptrend*0.420.030.0001
    Duration (y)
        <252501.2 (1.0-1.4)411.8 (1.3-2.5)122.2 (1.2-4.0)0.001
        25 to <35502.0 (1.4-2.7)1172.2 (1.8-2.8)703.5 (2.7-4.6)0.03
        ≥3510.8 (0.1-6.4)562.4 (1.7-3.2)4284.0 (3.4-4.6)0.002
        Ptrend*0.020.140.01
    Pack-years
        <302541.2 (1.1-1.5)1011.8 (1.5-2.3)1593.2 (2.6-3.8)<0.0001
        30 to <40221.6 (1.0-2.6)362.9 (2.0-4.2)1193.8 (3.1-4.8)0.005
        ≥40191.6 (1.0-2.5)722.4 (1.9-3.2)2274.7 (3.9-5.6)<0.0001
        Ptrend*0.410.080.0001
Adenomas only
    Cigarettes smoked per day
        1-101561.0 (0.8-1.2)451.1 (0.8-1.4)881.4 (1.1-1.8)0.007
        11-201910.9 (0.8-1.1)971.2 (1.0-1.5)2041.7 (1.4-2.0)<0.0001
        ≥211771.0 (0.9-1.2)1451.3 (1.1-1.6)2201.7 (1.4-2.0)<0.0001
        Ptrend*0.910.100.32
    Duration (y)
        <254421.0 (0.8-1.1)601.2 (0.9-1.6)181.6 (1.0-2.6)0.001
        25 to <35741.1 (0.9-1.5)1521.3 (1.1-1.5)541.3 (0.9-1.7)0.28
        ≥3541.4 (0.5-3.9)741.2 (0.9-1.5)4411.7 (1.5-1.9)0.007
        Ptrend*0.060.160.37
    Pack-years
        <304451.0 (0.8-1.1)1431.1 (1.0-1.4)1601.4 (1.2-1.7)<0.0001
        30 to <40250.8 (0.5-1.2)421.4 (1.0-1.9)1261.7 (1.4-2.1)0.001
        ≥40431.4 (1.0-2.0)931.3 (1.0-1.6)2201.8 (1.5-2.1)0.06
        Ptrend*0.090.160.20
Concurrent hyperplastic polyps and adenomas
    Cigarettes smoked per day
        1-10231.3 (0.8-2.0)153.1 (1.8-5.3)223.1 (1.9-5.0)0.002
        11-20311.2 (0.8-1.8)212.2 (1.4-3.6)886.1 (4.5-8.2)<0.0001
        ≥21371.8 (1.2-2.6)352.7 (1.8-4.0)875.8 (4.2-7.9)<0.0001
        Ptrend*0.300.820.05
    Duration (y)
        <25771.4 (1.0-1.8)132.3 (1.3-4.2)53.7 (1.5-9.2)0.01
        25 to <35141.8 (1.0-3.0)342.3 (1.6-3.5)214.4 (2.7-7.2)0.01
        ≥350243.3 (2.0-5.2)1705.5 (4.2-7.2)0.02
        Ptrend*0.510.510.19
    Pack-years
        <30751.3 (1.0-1.8)342.3 (1.6-3.5)534.2 (3.0-5.9)<0.0001
        30 to <40112.7 (1.4-5.1)102.9 (1.5-5.6)566.2 (4.4-8.8)<0.0001
        ≥4041.1 (0.4-2.9)242.7 (1.7-4.3)855.9 (4.3-8.0)<0.0001
        Ptrend*0.760.620.09
  • NOTE: ORs compared with never tobacco users and adjusted for age, sex, education, fruit, alcohol intake, and study centers.

    Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval.

  • * Dose-response trends were tested by using logistic regression among ever smokers only.